The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac

The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac

Brush border gene regulation in various different tissues is incompletely understood. Here, the authors show HNF4 regulates the brush border gene program in multiple organs, such as intestine, kidney and yolk sac, and also intestinal chromatin looping in these tissues between promoters and enhancers...

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Autores principales: Lei Chen, Shirley Luo, Abigail Dupre, Roshan P. Vasoya, Aditya Parthasarathy, Rohit Aita, Raj Malhotra, Joseph Hur, Natalie H. Toke, Eric Chiles, Min Yang, Weihuan Cao, Juan Flores, Christopher E. Ellison, Nan Gao, Amrik Sahota, Xiaoyang Su, Edward M. Bonder, Michael P. Verzi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5b2c764533374b2391e6fb24a9437a11
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spelling oai:doaj.org-article:5b2c764533374b2391e6fb24a9437a112021-12-02T14:58:51ZThe nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac10.1038/s41467-021-22761-52041-1723https://doaj.org/article/5b2c764533374b2391e6fb24a9437a112021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22761-5https://doaj.org/toc/2041-1723Brush border gene regulation in various different tissues is incompletely understood. Here, the authors show HNF4 regulates the brush border gene program in multiple organs, such as intestine, kidney and yolk sac, and also intestinal chromatin looping in these tissues between promoters and enhancers.Lei ChenShirley LuoAbigail DupreRoshan P. VasoyaAditya ParthasarathyRohit AitaRaj MalhotraJoseph HurNatalie H. TokeEric ChilesMin YangWeihuan CaoJuan FloresChristopher E. EllisonNan GaoAmrik SahotaXiaoyang SuEdward M. BonderMichael P. VerziNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lei Chen
Shirley Luo
Abigail Dupre
Roshan P. Vasoya
Aditya Parthasarathy
Rohit Aita
Raj Malhotra
Joseph Hur
Natalie H. Toke
Eric Chiles
Min Yang
Weihuan Cao
Juan Flores
Christopher E. Ellison
Nan Gao
Amrik Sahota
Xiaoyang Su
Edward M. Bonder
Michael P. Verzi
The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac
description Brush border gene regulation in various different tissues is incompletely understood. Here, the authors show HNF4 regulates the brush border gene program in multiple organs, such as intestine, kidney and yolk sac, and also intestinal chromatin looping in these tissues between promoters and enhancers.
format article
author Lei Chen
Shirley Luo
Abigail Dupre
Roshan P. Vasoya
Aditya Parthasarathy
Rohit Aita
Raj Malhotra
Joseph Hur
Natalie H. Toke
Eric Chiles
Min Yang
Weihuan Cao
Juan Flores
Christopher E. Ellison
Nan Gao
Amrik Sahota
Xiaoyang Su
Edward M. Bonder
Michael P. Verzi
author_facet Lei Chen
Shirley Luo
Abigail Dupre
Roshan P. Vasoya
Aditya Parthasarathy
Rohit Aita
Raj Malhotra
Joseph Hur
Natalie H. Toke
Eric Chiles
Min Yang
Weihuan Cao
Juan Flores
Christopher E. Ellison
Nan Gao
Amrik Sahota
Xiaoyang Su
Edward M. Bonder
Michael P. Verzi
author_sort Lei Chen
title The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac
title_short The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac
title_full The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac
title_fullStr The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac
title_full_unstemmed The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac
title_sort nuclear receptor hnf4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5b2c764533374b2391e6fb24a9437a11
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