Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress

In haploid budding yeast, evolutionary adaptation to constitutive DNA replication stress alters three genome maintenance modules: DNA replication, the DNA damage checkpoint, and sister chromatid cohesion. We asked how these trajectories depend on genomic features by comparing the adaptation in three...

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Bibliographic Details
Main Authors: Marco Fumasoni, Andrew W. Murray
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Online Access:https://doaj.org/article/5b2d4bd9754149f6b69d814af7325e3e
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