TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis

Increased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor cells, leading to reduced osteoblast differentiatio...

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Autores principales:	Jinbo Li, Akram Ayoub, Yan Xiu, Xiaoxiang Yin, James O. Sanders, Addisu Mesfin, Lianping Xing, Zhenqiang Yao, Brendan F. Boyce
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b2df4499d844e86910a28da5979f452
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spelling	oai:doaj.org-article:5b2df4499d844e86910a28da5979f4522021-12-02T14:38:58ZTGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis10.1038/s41467-019-10677-02041-1723https://doaj.org/article/5b2df4499d844e86910a28da5979f4522019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10677-0https://doaj.org/toc/2041-1723Increased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor cells, leading to reduced osteoblast differentiation and increased osteoclast formation, and suggesting that pharmacological stabilization of TRAF3 could ameliorate age-related osteoporosis.Jinbo LiAkram AyoubYan XiuXiaoxiang YinJames O. SandersAddisu MesfinLianping XingZhenqiang YaoBrendan F. BoyceNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinbo Li Akram Ayoub Yan Xiu Xiaoxiang Yin James O. Sanders Addisu Mesfin Lianping Xing Zhenqiang Yao Brendan F. Boyce TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
description	Increased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor cells, leading to reduced osteoblast differentiation and increased osteoclast formation, and suggesting that pharmacological stabilization of TRAF3 could ameliorate age-related osteoporosis.
format	article
author	Jinbo Li Akram Ayoub Yan Xiu Xiaoxiang Yin James O. Sanders Addisu Mesfin Lianping Xing Zhenqiang Yao Brendan F. Boyce
author_facet	Jinbo Li Akram Ayoub Yan Xiu Xiaoxiang Yin James O. Sanders Addisu Mesfin Lianping Xing Zhenqiang Yao Brendan F. Boyce
author_sort	Jinbo Li
title	TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
title_short	TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
title_full	TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
title_fullStr	TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
title_full_unstemmed	TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
title_sort	tgfβ-induced degradation of traf3 in mesenchymal progenitor cells causes age-related osteoporosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5b2df4499d844e86910a28da5979f452
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TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis

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