From bench to bar side: Evaluating the red wine storage lesion

Vitally essential red fluids like packed cells and red wine are seriously influenced in quality when stored over prolonged periods. In the case of red cell concentrates, the resulting storage lesion has particular significance in perioperative medicine. We hypothesized that, in contrast, aging rathe...

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Autores principales:	Klaschik Sven, Ellerkmann Richard K., Gehlen Jennifer, Frede Stilla, Hilbert Tobias
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	transfusion perioperative care wine resveratrol antioxidants hep g2 cells Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5b39bb356f214369a01bb718608089d6
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spelling	oai:doaj.org-article:5b39bb356f214369a01bb718608089d62021-12-05T14:10:41ZFrom bench to bar side: Evaluating the red wine storage lesion2391-541210.1515/biol-2021-0089https://doaj.org/article/5b39bb356f214369a01bb718608089d62021-08-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0089https://doaj.org/toc/2391-5412Vitally essential red fluids like packed cells and red wine are seriously influenced in quality when stored over prolonged periods. In the case of red cell concentrates, the resulting storage lesion has particular significance in perioperative medicine. We hypothesized that, in contrast, aging rather improves the properties of red wine in several ways. A translational approach, including (I) in vitro experiments, (II) a randomized, blinded crossover trial of acute clinical effects, and (III) a standardized red wine blind tasting was used. Three monovarietal wines (Cabernet Sauvignon, Chianti, Shiraz) in three different vintages (range 2004–2016), each 5 years different, were assessed. Assessments were performed at a German university hospital (I, II) and on a garden terrace during a mild summer evening (III). Young wines induced cell stress and damage while significantly reducing cytoprotective proteins in HepG2 hepatoma cells. Sympathetic activity and multitasking skills were altered depending on wines’ ages. Hangovers tended to be aggravated by young red wine. Aged variants performed better in terms of aroma and overall quality but worse in optical appearance. We found no evidence for a red wine storage lesion. However, we plead for consensus-based guidelines for proper storage, as it is common in clinical medicine.Klaschik SvenEllerkmann Richard K.Gehlen JenniferFrede StillaHilbert TobiasDe Gruyterarticletransfusionperioperative carewineresveratrolantioxidantshep g2 cellsBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 872-883 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	transfusion perioperative care wine resveratrol antioxidants hep g2 cells Biology (General) QH301-705.5
spellingShingle	transfusion perioperative care wine resveratrol antioxidants hep g2 cells Biology (General) QH301-705.5 Klaschik Sven Ellerkmann Richard K. Gehlen Jennifer Frede Stilla Hilbert Tobias From bench to bar side: Evaluating the red wine storage lesion
description	Vitally essential red fluids like packed cells and red wine are seriously influenced in quality when stored over prolonged periods. In the case of red cell concentrates, the resulting storage lesion has particular significance in perioperative medicine. We hypothesized that, in contrast, aging rather improves the properties of red wine in several ways. A translational approach, including (I) in vitro experiments, (II) a randomized, blinded crossover trial of acute clinical effects, and (III) a standardized red wine blind tasting was used. Three monovarietal wines (Cabernet Sauvignon, Chianti, Shiraz) in three different vintages (range 2004–2016), each 5 years different, were assessed. Assessments were performed at a German university hospital (I, II) and on a garden terrace during a mild summer evening (III). Young wines induced cell stress and damage while significantly reducing cytoprotective proteins in HepG2 hepatoma cells. Sympathetic activity and multitasking skills were altered depending on wines’ ages. Hangovers tended to be aggravated by young red wine. Aged variants performed better in terms of aroma and overall quality but worse in optical appearance. We found no evidence for a red wine storage lesion. However, we plead for consensus-based guidelines for proper storage, as it is common in clinical medicine.
format	article
author	Klaschik Sven Ellerkmann Richard K. Gehlen Jennifer Frede Stilla Hilbert Tobias
author_facet	Klaschik Sven Ellerkmann Richard K. Gehlen Jennifer Frede Stilla Hilbert Tobias
author_sort	Klaschik Sven
title	From bench to bar side: Evaluating the red wine storage lesion
title_short	From bench to bar side: Evaluating the red wine storage lesion
title_full	From bench to bar side: Evaluating the red wine storage lesion
title_fullStr	From bench to bar side: Evaluating the red wine storage lesion
title_full_unstemmed	From bench to bar side: Evaluating the red wine storage lesion
title_sort	from bench to bar side: evaluating the red wine storage lesion
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/5b39bb356f214369a01bb718608089d6
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From bench to bar side: Evaluating the red wine storage lesion

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