Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation

Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation

The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D genome architecture during normal B cell differenti...

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Autores principales: Roser Vilarrasa-Blasi, Paula Soler-Vila, Núria Verdaguer-Dot, Núria Russiñol, Marco Di Stefano, Vicente Chapaprieta, Guillem Clot, Irene Farabella, Pol Cuscó, Marta Kulis, Xabier Agirre, Felipe Prosper, Renée Beekman, Silvia Beà, Dolors Colomer, Hendrik G. Stunnenberg, Ivo Gut, Elias Campo, Marc A. Marti-Renom, José Ignacio Martin-Subero
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5b3e5737815642a5840183e2effa2f69
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spelling oai:doaj.org-article:5b3e5737815642a5840183e2effa2f692021-12-02T10:48:09ZDynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation10.1038/s41467-020-20849-y2041-1723https://doaj.org/article/5b3e5737815642a5840183e2effa2f692021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20849-yhttps://doaj.org/toc/2041-1723The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D genome architecture during normal B cell differentiation and in neoplastic cells from chronic lymphocytic leukemia and mantle cell lymphoma patients.Roser Vilarrasa-BlasiPaula Soler-VilaNúria Verdaguer-DotNúria RussiñolMarco Di StefanoVicente ChapaprietaGuillem ClotIrene FarabellaPol CuscóMarta KulisXabier AgirreFelipe ProsperRenée BeekmanSilvia BeàDolors ColomerHendrik G. StunnenbergIvo GutElias CampoMarc A. Marti-RenomJosé Ignacio Martin-SuberoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Roser Vilarrasa-Blasi
Paula Soler-Vila
Núria Verdaguer-Dot
Núria Russiñol
Marco Di Stefano
Vicente Chapaprieta
Guillem Clot
Irene Farabella
Pol Cuscó
Marta Kulis
Xabier Agirre
Felipe Prosper
Renée Beekman
Silvia Beà
Dolors Colomer
Hendrik G. Stunnenberg
Ivo Gut
Elias Campo
Marc A. Marti-Renom
José Ignacio Martin-Subero
Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
description The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D genome architecture during normal B cell differentiation and in neoplastic cells from chronic lymphocytic leukemia and mantle cell lymphoma patients.
format article
author Roser Vilarrasa-Blasi
Paula Soler-Vila
Núria Verdaguer-Dot
Núria Russiñol
Marco Di Stefano
Vicente Chapaprieta
Guillem Clot
Irene Farabella
Pol Cuscó
Marta Kulis
Xabier Agirre
Felipe Prosper
Renée Beekman
Silvia Beà
Dolors Colomer
Hendrik G. Stunnenberg
Ivo Gut
Elias Campo
Marc A. Marti-Renom
José Ignacio Martin-Subero
author_facet Roser Vilarrasa-Blasi
Paula Soler-Vila
Núria Verdaguer-Dot
Núria Russiñol
Marco Di Stefano
Vicente Chapaprieta
Guillem Clot
Irene Farabella
Pol Cuscó
Marta Kulis
Xabier Agirre
Felipe Prosper
Renée Beekman
Silvia Beà
Dolors Colomer
Hendrik G. Stunnenberg
Ivo Gut
Elias Campo
Marc A. Marti-Renom
José Ignacio Martin-Subero
author_sort Roser Vilarrasa-Blasi
title Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
title_short Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
title_full Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
title_fullStr Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
title_full_unstemmed Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
title_sort dynamics of genome architecture and chromatin function during human b cell differentiation and neoplastic transformation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5b3e5737815642a5840183e2effa2f69
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