Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial

Background: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle that affects many teenagers and young people. There is an obvious need for topical treatments with good tolerability and efficacy for the management of acne lesions. Objective: This study determined the ther...

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Autores principales:	Azadeh Dorostkar, Mehdi Ghahartars, Mohammad Reza Namazi, Nafiseh Todarbary, Maryam Hadibarhaghtalab, Maryam Rezaee
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2021
Materias:	topical sodium hypoclorite 0.005% acne treatment Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/5b4381e201fb460d915dc2cbb8be3e2e
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spelling	oai:doaj.org-article:5b4381e201fb460d915dc2cbb8be3e2e2021-11-17T08:27:54ZSodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial 10.5826/dpc.1103a462160-9381https://doaj.org/article/5b4381e201fb460d915dc2cbb8be3e2e2021-05-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1565https://doaj.org/toc/2160-9381 Background: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle that affects many teenagers and young people. There is an obvious need for topical treatments with good tolerability and efficacy for the management of acne lesions. Objective: This study determined the therapeutic efficacy of topical sodium hypochlorite solution (0.005%) in the treatment of mild to moderate acne lesions. Methods: This placebo-controlled randomized controlled trial compared 0.005% sodium hypochlorite to placebo administered topically on each side of the patients’ faces 3 times a day for 1 month. The numbers of papules and pustules were recorded at baseline, 1, 2 and 4 weeks after initiation. Results: The total number of papules and pustules decreased after topical application of sodium hypochlorite 0.005% for 1 month. Conclusions: Topical sodium hypochlorite solution (0.005%) can be effective in the treatment of mild to moderate acne, and its clinical efficacy was evaluated between the male and female groups and between the hormonal and non-hormonal ones. Trial registration: Our study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code number IRCT20200701047976N1. Azadeh DorostkarMehdi GhahartarsMohammad Reza NamaziNafiseh TodarbaryMaryam HadibarhaghtalabMaryam RezaeeMattioli1885articletopicalsodium hypoclorite 0.005%acnetreatmentDermatologyRL1-803ENDermatology Practical & Conceptual (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	topical sodium hypoclorite 0.005% acne treatment Dermatology RL1-803
spellingShingle	topical sodium hypoclorite 0.005% acne treatment Dermatology RL1-803 Azadeh Dorostkar Mehdi Ghahartars Mohammad Reza Namazi Nafiseh Todarbary Maryam Hadibarhaghtalab Maryam Rezaee Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial
description	Background: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle that affects many teenagers and young people. There is an obvious need for topical treatments with good tolerability and efficacy for the management of acne lesions. Objective: This study determined the therapeutic efficacy of topical sodium hypochlorite solution (0.005%) in the treatment of mild to moderate acne lesions. Methods: This placebo-controlled randomized controlled trial compared 0.005% sodium hypochlorite to placebo administered topically on each side of the patients’ faces 3 times a day for 1 month. The numbers of papules and pustules were recorded at baseline, 1, 2 and 4 weeks after initiation. Results: The total number of papules and pustules decreased after topical application of sodium hypochlorite 0.005% for 1 month. Conclusions: Topical sodium hypochlorite solution (0.005%) can be effective in the treatment of mild to moderate acne, and its clinical efficacy was evaluated between the male and female groups and between the hormonal and non-hormonal ones. Trial registration: Our study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code number IRCT20200701047976N1.
format	article
author	Azadeh Dorostkar Mehdi Ghahartars Mohammad Reza Namazi Nafiseh Todarbary Maryam Hadibarhaghtalab Maryam Rezaee
author_facet	Azadeh Dorostkar Mehdi Ghahartars Mohammad Reza Namazi Nafiseh Todarbary Maryam Hadibarhaghtalab Maryam Rezaee
author_sort	Azadeh Dorostkar
title	Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial
title_short	Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial
title_full	Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial
title_fullStr	Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial
title_full_unstemmed	Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial
title_sort	sodium hypochlorite 0.005% versus placebo in the treatment of mild to moderate acne: a double-blind randomized controlled trial
publisher	Mattioli1885
publishDate	2021
url	https://doaj.org/article/5b4381e201fb460d915dc2cbb8be3e2e
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Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial

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