The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization

Metabolites act as enzyme inhibitors, but their global impact on metabolism has scarcely been considered. Here, the authors generate a human genome-wide metabolite-enzyme inhibition network, and find that inhibition occurs largely due to limited structural diversity of metabolites, leading to a glob...

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Autores principales:	Mohammad Tauqeer Alam, Viridiana Olin-Sandoval, Anna Stincone, Markus A. Keller, Aleksej Zelezniak, Ben F. Luisi, Markus Ralser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b49414707024d1da2e15bb11e65187f
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spelling	oai:doaj.org-article:5b49414707024d1da2e15bb11e65187f2021-12-02T17:06:27ZThe self-inhibitory nature of metabolic networks and its alleviation through compartmentalization10.1038/ncomms160182041-1723https://doaj.org/article/5b49414707024d1da2e15bb11e65187f2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16018https://doaj.org/toc/2041-1723Metabolites act as enzyme inhibitors, but their global impact on metabolism has scarcely been considered. Here, the authors generate a human genome-wide metabolite-enzyme inhibition network, and find that inhibition occurs largely due to limited structural diversity of metabolites, leading to a global constraint on metabolism which subcellular compartmentalization minimizes.Mohammad Tauqeer AlamViridiana Olin-SandovalAnna StinconeMarkus A. KellerAleksej ZelezniakBen F. LuisiMarkus RalserNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohammad Tauqeer Alam Viridiana Olin-Sandoval Anna Stincone Markus A. Keller Aleksej Zelezniak Ben F. Luisi Markus Ralser The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization
description	Metabolites act as enzyme inhibitors, but their global impact on metabolism has scarcely been considered. Here, the authors generate a human genome-wide metabolite-enzyme inhibition network, and find that inhibition occurs largely due to limited structural diversity of metabolites, leading to a global constraint on metabolism which subcellular compartmentalization minimizes.
format	article
author	Mohammad Tauqeer Alam Viridiana Olin-Sandoval Anna Stincone Markus A. Keller Aleksej Zelezniak Ben F. Luisi Markus Ralser
author_facet	Mohammad Tauqeer Alam Viridiana Olin-Sandoval Anna Stincone Markus A. Keller Aleksej Zelezniak Ben F. Luisi Markus Ralser
author_sort	Mohammad Tauqeer Alam
title	The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization
title_short	The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization
title_full	The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization
title_fullStr	The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization
title_full_unstemmed	The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization
title_sort	self-inhibitory nature of metabolic networks and its alleviation through compartmentalization
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5b49414707024d1da2e15bb11e65187f
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The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization

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