Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy

Radiotherapy promotes tumor cell death and senescence through the induction of oxidative damage. Recent work has highlighted the importance of lipid peroxidation for radiotherapy efficacy. Excessive lipid peroxidation can promote ferroptosis, a regulated form of cell death. In this review, we addres...

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Main Authors:	Ashley N. Pearson, Joseph Carmicheal, Long Jiang, Yu Leo Lei, Michael D. Green
Format:	article
Language:	EN
Published:	MDPI AG 2021
Subjects:	lipid oxidation ferroptosis radiotherapy Biology (General) QH301-705.5 Chemistry QD1-999
Online Access:	https://doaj.org/article/5b4a7ed5e11a4465a7602a24eee38ea1
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spelling	oai:doaj.org-article:5b4a7ed5e11a4465a7602a24eee38ea12021-11-25T17:58:14ZContribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy10.3390/ijms2222126031422-00671661-6596https://doaj.org/article/5b4a7ed5e11a4465a7602a24eee38ea12021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12603https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Radiotherapy promotes tumor cell death and senescence through the induction of oxidative damage. Recent work has highlighted the importance of lipid peroxidation for radiotherapy efficacy. Excessive lipid peroxidation can promote ferroptosis, a regulated form of cell death. In this review, we address the evidence supporting a role of ferroptosis in response to radiotherapy and discuss the molecular regulators that underlie this interaction. Finally, we postulate on the clinical implications for the intersection of ferroptosis and radiotherapy.Ashley N. PearsonJoseph CarmichealLong JiangYu Leo LeiMichael D. GreenMDPI AGarticlelipid oxidationferroptosisradiotherapyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12603, p 12603 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lipid oxidation ferroptosis radiotherapy Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	lipid oxidation ferroptosis radiotherapy Biology (General) QH301-705.5 Chemistry QD1-999 Ashley N. Pearson Joseph Carmicheal Long Jiang Yu Leo Lei Michael D. Green Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy
description	Radiotherapy promotes tumor cell death and senescence through the induction of oxidative damage. Recent work has highlighted the importance of lipid peroxidation for radiotherapy efficacy. Excessive lipid peroxidation can promote ferroptosis, a regulated form of cell death. In this review, we address the evidence supporting a role of ferroptosis in response to radiotherapy and discuss the molecular regulators that underlie this interaction. Finally, we postulate on the clinical implications for the intersection of ferroptosis and radiotherapy.
format	article
author	Ashley N. Pearson Joseph Carmicheal Long Jiang Yu Leo Lei Michael D. Green
author_facet	Ashley N. Pearson Joseph Carmicheal Long Jiang Yu Leo Lei Michael D. Green
author_sort	Ashley N. Pearson
title	Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy
title_short	Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy
title_full	Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy
title_fullStr	Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy
title_full_unstemmed	Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy
title_sort	contribution of lipid oxidation and ferroptosis to radiotherapy efficacy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5b4a7ed5e11a4465a7602a24eee38ea1
work_keys_str_mv	AT ashleynpearson contributionoflipidoxidationandferroptosistoradiotherapyefficacy AT josephcarmicheal contributionoflipidoxidationandferroptosistoradiotherapyefficacy AT longjiang contributionoflipidoxidationandferroptosistoradiotherapyefficacy AT yuleolei contributionoflipidoxidationandferroptosistoradiotherapyefficacy AT michaeldgreen contributionoflipidoxidationandferroptosistoradiotherapyefficacy
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Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy

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