A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling

Wu et al. demonstrate that KCNE1 exerts its effects on potassium channel KCNQ1 function by regulating the coupling between the voltage-sensing domain and pore domain via KCNE1-induced rotation. As a consequence of this rotation, residue clashes occur that prohibit the formation of a conductive inter...

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Autores principales:	Xiaoan Wu, Marta E. Perez, Sergei Yu Noskov, H. Peter Larsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5b4b4545350a401c9a25abae93fba693
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spelling	oai:doaj.org-article:5b4b4545350a401c9a25abae93fba6932021-12-02T16:17:32ZA general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling10.1038/s42003-021-02418-12399-3642https://doaj.org/article/5b4b4545350a401c9a25abae93fba6932021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02418-1https://doaj.org/toc/2399-3642Wu et al. demonstrate that KCNE1 exerts its effects on potassium channel KCNQ1 function by regulating the coupling between the voltage-sensing domain and pore domain via KCNE1-induced rotation. As a consequence of this rotation, residue clashes occur that prohibit the formation of a conductive intermediate state conformation of the voltage sensor.Xiaoan WuMarta E. PerezSergei Yu NoskovH. Peter LarssonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Xiaoan Wu Marta E. Perez Sergei Yu Noskov H. Peter Larsson A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling
description	Wu et al. demonstrate that KCNE1 exerts its effects on potassium channel KCNQ1 function by regulating the coupling between the voltage-sensing domain and pore domain via KCNE1-induced rotation. As a consequence of this rotation, residue clashes occur that prohibit the formation of a conductive intermediate state conformation of the voltage sensor.
format	article
author	Xiaoan Wu Marta E. Perez Sergei Yu Noskov H. Peter Larsson
author_facet	Xiaoan Wu Marta E. Perez Sergei Yu Noskov H. Peter Larsson
author_sort	Xiaoan Wu
title	A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling
title_short	A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling
title_full	A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling
title_fullStr	A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling
title_full_unstemmed	A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling
title_sort	general mechanism of kcne1 modulation of kcnq1 channels involving non-canonical vsd-pd coupling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b4b4545350a401c9a25abae93fba693
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A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling

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