A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling
Wu et al. demonstrate that KCNE1 exerts its effects on potassium channel KCNQ1 function by regulating the coupling between the voltage-sensing domain and pore domain via KCNE1-induced rotation. As a consequence of this rotation, residue clashes occur that prohibit the formation of a conductive inter...
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| Main Authors: | , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/5b4b4545350a401c9a25abae93fba693 |
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