Rapid multi-directed cholinergic transmission in the central nervous system

Cholinergic neurons may transmit information via fast synaptic, point-to-point signaling or diffuse, slow extra-synaptic signaling. The authors show that ACh from a single vesicle triggers synchronous miniature currents in two neurons, showing that ACh can spread significant distances to drive rapid...

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Autores principales:	Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin Murphy-Baum, J Michael McIntosh, Miao Jing, Yulong Li, David Berson, Keisuke Yonehara, Gautam B. Awatramani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b4feb7a3c6b447298dcba902c79f327
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spelling	oai:doaj.org-article:5b4feb7a3c6b447298dcba902c79f3272021-12-02T13:33:01ZRapid multi-directed cholinergic transmission in the central nervous system10.1038/s41467-021-21680-92041-1723https://doaj.org/article/5b4feb7a3c6b447298dcba902c79f3272021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21680-9https://doaj.org/toc/2041-1723Cholinergic neurons may transmit information via fast synaptic, point-to-point signaling or diffuse, slow extra-synaptic signaling. The authors show that ACh from a single vesicle triggers synchronous miniature currents in two neurons, showing that ACh can spread significant distances to drive rapid ‘synaptic’ signals.Santhosh SethuramanujamAkihiro MatsumotoGeoff deRosenrollBenjamin Murphy-BaumJ Michael McIntoshMiao JingYulong LiDavid BersonKeisuke YoneharaGautam B. AwatramaniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Santhosh Sethuramanujam Akihiro Matsumoto Geoff deRosenroll Benjamin Murphy-Baum J Michael McIntosh Miao Jing Yulong Li David Berson Keisuke Yonehara Gautam B. Awatramani Rapid multi-directed cholinergic transmission in the central nervous system
description	Cholinergic neurons may transmit information via fast synaptic, point-to-point signaling or diffuse, slow extra-synaptic signaling. The authors show that ACh from a single vesicle triggers synchronous miniature currents in two neurons, showing that ACh can spread significant distances to drive rapid ‘synaptic’ signals.
format	article
author	Santhosh Sethuramanujam Akihiro Matsumoto Geoff deRosenroll Benjamin Murphy-Baum J Michael McIntosh Miao Jing Yulong Li David Berson Keisuke Yonehara Gautam B. Awatramani
author_facet	Santhosh Sethuramanujam Akihiro Matsumoto Geoff deRosenroll Benjamin Murphy-Baum J Michael McIntosh Miao Jing Yulong Li David Berson Keisuke Yonehara Gautam B. Awatramani
author_sort	Santhosh Sethuramanujam
title	Rapid multi-directed cholinergic transmission in the central nervous system
title_short	Rapid multi-directed cholinergic transmission in the central nervous system
title_full	Rapid multi-directed cholinergic transmission in the central nervous system
title_fullStr	Rapid multi-directed cholinergic transmission in the central nervous system
title_full_unstemmed	Rapid multi-directed cholinergic transmission in the central nervous system
title_sort	rapid multi-directed cholinergic transmission in the central nervous system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b4feb7a3c6b447298dcba902c79f327
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Rapid multi-directed cholinergic transmission in the central nervous system

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