Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner

Virtual memory T cells are CD8 T cells with memory phenotype present in unimmunized mice. Here the authors show that these cells have higher affinity for self-antigen, depend on IL-15 for proliferation and antigen-non-specific cytotoxicity in mice, and that a similar population exists in humans.

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Detalles Bibliográficos
Autores principales:	Jason T. White, Eric W. Cross, Matthew A. Burchill, Thomas Danhorn, Martin D. McCarter, Hugo R. Rosen, Brian O’Connor, Ross M. Kedl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b504adf9a774808aa2014fe7ae6ebee
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spelling	oai:doaj.org-article:5b504adf9a774808aa2014fe7ae6ebee2021-12-02T16:50:15ZVirtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner10.1038/ncomms112912041-1723https://doaj.org/article/5b504adf9a774808aa2014fe7ae6ebee2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11291https://doaj.org/toc/2041-1723Virtual memory T cells are CD8 T cells with memory phenotype present in unimmunized mice. Here the authors show that these cells have higher affinity for self-antigen, depend on IL-15 for proliferation and antigen-non-specific cytotoxicity in mice, and that a similar population exists in humans.Jason T. WhiteEric W. CrossMatthew A. BurchillThomas DanhornMartin D. McCarterHugo R. RosenBrian O’ConnorRoss M. KedlNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason T. White Eric W. Cross Matthew A. Burchill Thomas Danhorn Martin D. McCarter Hugo R. Rosen Brian O’Connor Ross M. Kedl Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner
description	Virtual memory T cells are CD8 T cells with memory phenotype present in unimmunized mice. Here the authors show that these cells have higher affinity for self-antigen, depend on IL-15 for proliferation and antigen-non-specific cytotoxicity in mice, and that a similar population exists in humans.
format	article
author	Jason T. White Eric W. Cross Matthew A. Burchill Thomas Danhorn Martin D. McCarter Hugo R. Rosen Brian O’Connor Ross M. Kedl
author_facet	Jason T. White Eric W. Cross Matthew A. Burchill Thomas Danhorn Martin D. McCarter Hugo R. Rosen Brian O’Connor Ross M. Kedl
author_sort	Jason T. White
title	Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner
title_short	Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner
title_full	Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner
title_fullStr	Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner
title_full_unstemmed	Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner
title_sort	virtual memory t cells develop and mediate bystander protective immunity in an il-15-dependent manner
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5b504adf9a774808aa2014fe7ae6ebee
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Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner

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