Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast

In yeast, Hda1 histone deacetylase complex (Hda1C) preferentially deacetylates H3 and H2B, but has also been implicated in global H4 deacetylation. Here, the authors provide evidence that Hda1C binds to hyperactive genes, where it specifically deacetylates H4 to partially inhibit elongation, suggest...

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Autores principales:	So Dam Ha, Seokjin Ham, Min Young Kim, Ji Hyun Kim, Insoon Jang, Bo Bae Lee, Min Kyung Lee, Jin-Taek Hwang, Tae-Young Roh, TaeSoo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b53513e9eb54d71820ab18fd6d3ee68
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spelling	oai:doaj.org-article:5b53513e9eb54d71820ab18fd6d3ee682021-12-02T16:57:07ZTranscription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast10.1038/s41467-019-12077-w2041-1723https://doaj.org/article/5b53513e9eb54d71820ab18fd6d3ee682019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12077-whttps://doaj.org/toc/2041-1723In yeast, Hda1 histone deacetylase complex (Hda1C) preferentially deacetylates H3 and H2B, but has also been implicated in global H4 deacetylation. Here, the authors provide evidence that Hda1C binds to hyperactive genes, where it specifically deacetylates H4 to partially inhibit elongation, suggesting a role for Hda1C in elongation by specifically deacetylating H4 at highly transcribed regions.So Dam HaSeokjin HamMin Young KimJi Hyun KimInsoon JangBo Bae LeeMin Kyung LeeJin-Taek HwangTae-Young RohTaeSoo KimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q So Dam Ha Seokjin Ham Min Young Kim Ji Hyun Kim Insoon Jang Bo Bae Lee Min Kyung Lee Jin-Taek Hwang Tae-Young Roh TaeSoo Kim Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast
description	In yeast, Hda1 histone deacetylase complex (Hda1C) preferentially deacetylates H3 and H2B, but has also been implicated in global H4 deacetylation. Here, the authors provide evidence that Hda1C binds to hyperactive genes, where it specifically deacetylates H4 to partially inhibit elongation, suggesting a role for Hda1C in elongation by specifically deacetylating H4 at highly transcribed regions.
format	article
author	So Dam Ha Seokjin Ham Min Young Kim Ji Hyun Kim Insoon Jang Bo Bae Lee Min Kyung Lee Jin-Taek Hwang Tae-Young Roh TaeSoo Kim
author_facet	So Dam Ha Seokjin Ham Min Young Kim Ji Hyun Kim Insoon Jang Bo Bae Lee Min Kyung Lee Jin-Taek Hwang Tae-Young Roh TaeSoo Kim
author_sort	So Dam Ha
title	Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast
title_short	Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast
title_full	Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast
title_fullStr	Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast
title_full_unstemmed	Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast
title_sort	transcription-dependent targeting of hda1c to hyperactive genes mediates h4-specific deacetylation in yeast
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5b53513e9eb54d71820ab18fd6d3ee68
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Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast

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