Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast

In yeast, Hda1 histone deacetylase complex (Hda1C) preferentially deacetylates H3 and H2B, but has also been implicated in global H4 deacetylation. Here, the authors provide evidence that Hda1C binds to hyperactive genes, where it specifically deacetylates H4 to partially inhibit elongation, suggest...

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Autores principales: So Dam Ha, Seokjin Ham, Min Young Kim, Ji Hyun Kim, Insoon Jang, Bo Bae Lee, Min Kyung Lee, Jin-Taek Hwang, Tae-Young Roh, TaeSoo Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/5b53513e9eb54d71820ab18fd6d3ee68
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