Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.

The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response....

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Autores principales:	Alexandra Anderson, Henry Laurenson-Schafer, Frederick A Partridge, Jonathan Hodgkin, Rachel McMullan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5b5563aa67094fcd8065f123a03d6450
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spelling	oai:doaj.org-article:5b5563aa67094fcd8065f123a03d64502021-11-18T06:07:15ZSerotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.1553-73661553-737410.1371/journal.ppat.1003787https://doaj.org/article/5b5563aa67094fcd8065f123a03d64502013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24348250/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that serotonin, synthesized in Caenorhabditis elegans chemosensory neurons, modulates the immune response. Serotonin released from these cells acts, directly or indirectly, to regulate G-protein signaling in epithelial cells. Signaling in these cells is required for the immune response to infection by the natural pathogen Microbacterium nematophilum. Here we show that serotonin signaling suppresses the innate immune response and limits the rate of pathogen clearance. We show that C. elegans uses classical neurotransmitters to alter the immune response. Serotonin released from sensory neurons may function to modify the immune system in response to changes in the animal's external environment such as the availability, or quality, of food.Alexandra AndersonHenry Laurenson-SchaferFrederick A PartridgeJonathan HodgkinRachel McMullanPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 12, p e1003787 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Alexandra Anderson Henry Laurenson-Schafer Frederick A Partridge Jonathan Hodgkin Rachel McMullan Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.
description	The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that serotonin, synthesized in Caenorhabditis elegans chemosensory neurons, modulates the immune response. Serotonin released from these cells acts, directly or indirectly, to regulate G-protein signaling in epithelial cells. Signaling in these cells is required for the immune response to infection by the natural pathogen Microbacterium nematophilum. Here we show that serotonin signaling suppresses the innate immune response and limits the rate of pathogen clearance. We show that C. elegans uses classical neurotransmitters to alter the immune response. Serotonin released from sensory neurons may function to modify the immune system in response to changes in the animal's external environment such as the availability, or quality, of food.
format	article
author	Alexandra Anderson Henry Laurenson-Schafer Frederick A Partridge Jonathan Hodgkin Rachel McMullan
author_facet	Alexandra Anderson Henry Laurenson-Schafer Frederick A Partridge Jonathan Hodgkin Rachel McMullan
author_sort	Alexandra Anderson
title	Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.
title_short	Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.
title_full	Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.
title_fullStr	Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.
title_full_unstemmed	Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.
title_sort	serotonergic chemosensory neurons modify the c. elegans immune response by regulating g-protein signaling in epithelial cells.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5b5563aa67094fcd8065f123a03d6450
work_keys_str_mv	AT alexandraanderson serotonergicchemosensoryneuronsmodifythecelegansimmuneresponsebyregulatinggproteinsignalinginepithelialcells AT henrylaurensonschafer serotonergicchemosensoryneuronsmodifythecelegansimmuneresponsebyregulatinggproteinsignalinginepithelialcells AT frederickapartridge serotonergicchemosensoryneuronsmodifythecelegansimmuneresponsebyregulatinggproteinsignalinginepithelialcells AT jonathanhodgkin serotonergicchemosensoryneuronsmodifythecelegansimmuneresponsebyregulatinggproteinsignalinginepithelialcells AT rachelmcmullan serotonergicchemosensoryneuronsmodifythecelegansimmuneresponsebyregulatinggproteinsignalinginepithelialcells
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Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.

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