Clusters of Survivors of COVID-19 Associated Acute Respiratory Failure According to Response to Exercise

COVID-19 survivors are associated with acute respiratory failure (ARF) and show a high prevalence of impairment in physical performance. The present studied aimed to assess whether we may cluster these individuals according to an exercise test. The presented study is a retrospective analysis of 154...

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Autores principales:	Michele Vitacca, Mara Paneroni, Alberto Malovini, Annalisa Carlucci, Chiara Binda, Vincenzo Sanci, Nicolino Ambrosino
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acute respiratory failure dyspnoea exercise test exercise tolerance fatigue pulmonary rehabilitation Medicine R
Acceso en línea:	https://doaj.org/article/5b5c53a36f3b46e1ad7d2963968cc27f
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spelling	oai:doaj.org-article:5b5c53a36f3b46e1ad7d2963968cc27f2021-11-25T17:49:03ZClusters of Survivors of COVID-19 Associated Acute Respiratory Failure According to Response to Exercise10.3390/ijerph1822118681660-46011661-7827https://doaj.org/article/5b5c53a36f3b46e1ad7d2963968cc27f2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/11868https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601COVID-19 survivors are associated with acute respiratory failure (ARF) and show a high prevalence of impairment in physical performance. The present studied aimed to assess whether we may cluster these individuals according to an exercise test. The presented study is a retrospective analysis of 154 survivors who were admitted to two hospitals of Istituti Clinici Scientifici Maugeri network, Italy. Clinical characteristics, walked distance, heart rate (HR), pulse oximetry (SpO<sub>2</sub>), dyspnoea, and leg fatigue (Borg scale: Borg-D and Borg-F, respectively) while performing the six-minute walking test (6MWT) were entered into unsupervised clustering analysis. Multivariate linear regression identified variables that were informative for the set of variables used for cluster definition. Cluster 1 (C1: 86.4% of participants) and Cluster 2 (C2: 13.6%) were identified. Compared to C1, the individuals in C2 were significantly older, showed significantly higher increase in fatigue and in dyspnoea, greater reduction in SpO<sub>2</sub>, and a lower HR<sub>peak</sub> during the test. The need of walking aids, time from admission to acute care hospitals, age, body mass index, endotracheal intubation, baseline HR and baseline Borg-D, and exercise-induced SpO<sub>2</sub> <i>change</i> were significantly associated with the variables that were used for cluster definition. Different characteristics and physiological parameters during the 6MWT characterise survivors of COVID-19-associated ARF. These results may help in the management of the long-term effects of the disease.Michele VitaccaMara PaneroniAlberto MaloviniAnnalisa CarlucciChiara BindaVincenzo SanciNicolino AmbrosinoMDPI AGarticleacute respiratory failuredyspnoeaexercise testexercise tolerancefatiguepulmonary rehabilitationMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11868, p 11868 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute respiratory failure dyspnoea exercise test exercise tolerance fatigue pulmonary rehabilitation Medicine R
spellingShingle	acute respiratory failure dyspnoea exercise test exercise tolerance fatigue pulmonary rehabilitation Medicine R Michele Vitacca Mara Paneroni Alberto Malovini Annalisa Carlucci Chiara Binda Vincenzo Sanci Nicolino Ambrosino Clusters of Survivors of COVID-19 Associated Acute Respiratory Failure According to Response to Exercise
description	COVID-19 survivors are associated with acute respiratory failure (ARF) and show a high prevalence of impairment in physical performance. The present studied aimed to assess whether we may cluster these individuals according to an exercise test. The presented study is a retrospective analysis of 154 survivors who were admitted to two hospitals of Istituti Clinici Scientifici Maugeri network, Italy. Clinical characteristics, walked distance, heart rate (HR), pulse oximetry (SpO<sub>2</sub>), dyspnoea, and leg fatigue (Borg scale: Borg-D and Borg-F, respectively) while performing the six-minute walking test (6MWT) were entered into unsupervised clustering analysis. Multivariate linear regression identified variables that were informative for the set of variables used for cluster definition. Cluster 1 (C1: 86.4% of participants) and Cluster 2 (C2: 13.6%) were identified. Compared to C1, the individuals in C2 were significantly older, showed significantly higher increase in fatigue and in dyspnoea, greater reduction in SpO<sub>2</sub>, and a lower HR<sub>peak</sub> during the test. The need of walking aids, time from admission to acute care hospitals, age, body mass index, endotracheal intubation, baseline HR and baseline Borg-D, and exercise-induced SpO<sub>2</sub> <i>change</i> were significantly associated with the variables that were used for cluster definition. Different characteristics and physiological parameters during the 6MWT characterise survivors of COVID-19-associated ARF. These results may help in the management of the long-term effects of the disease.
format	article
author	Michele Vitacca Mara Paneroni Alberto Malovini Annalisa Carlucci Chiara Binda Vincenzo Sanci Nicolino Ambrosino
author_facet	Michele Vitacca Mara Paneroni Alberto Malovini Annalisa Carlucci Chiara Binda Vincenzo Sanci Nicolino Ambrosino
author_sort	Michele Vitacca
title	Clusters of Survivors of COVID-19 Associated Acute Respiratory Failure According to Response to Exercise
title_short	Clusters of Survivors of COVID-19 Associated Acute Respiratory Failure According to Response to Exercise
title_full	Clusters of Survivors of COVID-19 Associated Acute Respiratory Failure According to Response to Exercise
title_fullStr	Clusters of Survivors of COVID-19 Associated Acute Respiratory Failure According to Response to Exercise
title_full_unstemmed	Clusters of Survivors of COVID-19 Associated Acute Respiratory Failure According to Response to Exercise
title_sort	clusters of survivors of covid-19 associated acute respiratory failure according to response to exercise
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5b5c53a36f3b46e1ad7d2963968cc27f
work_keys_str_mv	AT michelevitacca clustersofsurvivorsofcovid19associatedacuterespiratoryfailureaccordingtoresponsetoexercise AT marapaneroni clustersofsurvivorsofcovid19associatedacuterespiratoryfailureaccordingtoresponsetoexercise AT albertomalovini clustersofsurvivorsofcovid19associatedacuterespiratoryfailureaccordingtoresponsetoexercise AT annalisacarlucci clustersofsurvivorsofcovid19associatedacuterespiratoryfailureaccordingtoresponsetoexercise AT chiarabinda clustersofsurvivorsofcovid19associatedacuterespiratoryfailureaccordingtoresponsetoexercise AT vincenzosanci clustersofsurvivorsofcovid19associatedacuterespiratoryfailureaccordingtoresponsetoexercise AT nicolinoambrosino clustersofsurvivorsofcovid19associatedacuterespiratoryfailureaccordingtoresponsetoexercise
_version_	1718411986899828736

Clusters of Survivors of COVID-19 Associated Acute Respiratory Failure According to Response to Exercise

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