Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells

Propolis is a natural product produced by bees that is primarily used in complementary and alternative medicine and has anti-inflammatory, antibacterial, antiviral, and antitumoral biological properties. Some studies have reported the beneficial effects of propolis in models of allergic asthma. In a...

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Autores principales:	Núbia Sabrina Martins, Thais Fernanda de Campos Fraga-Silva, Giseli Furlan Correa, Mèdéton Mahoussi Michaël Boko, Leandra Naira Zambelli Ramalho, Débora Munhoz Rodrigues, Juliana Issa Hori, Diego Luis Costa, Jairo Kenupp Bastos, Vânia Luiza Deperon Bonato
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	propolis artepillin C allergic asthma M-MDSC therapies Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/5b61279df6a2467895f4249b3f26a362
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spelling	oai:doaj.org-article:5b61279df6a2467895f4249b3f26a3622021-11-25T18:40:28ZArtepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells10.3390/pharmaceutics131117631999-4923https://doaj.org/article/5b61279df6a2467895f4249b3f26a3622021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1763https://doaj.org/toc/1999-4923Propolis is a natural product produced by bees that is primarily used in complementary and alternative medicine and has anti-inflammatory, antibacterial, antiviral, and antitumoral biological properties. Some studies have reported the beneficial effects of propolis in models of allergic asthma. In a previous study, our group showed that green propolis treatment reduced airway inflammation and mucus secretion in an ovalbumin (OVA)-induced asthma model and resulted in increased regulatory T cells (Treg) and polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) frequencies in the lungs, two leukocyte populations that have immunosuppressive functions. In this study, we evaluated the anti-inflammatory effects of artepillin C (ArtC), the major compound of green propolis, in the context of allergic airway inflammation. Our results show that ArtC induces in vitro differentiation of Treg cells and monocytic MDSC (M-MDSC). Furthermore, in an OVA-induced asthma model, ArtC treatment reduced pulmonary inflammation, eosinophil influx to the airways, mucus and IL-5 secretion along with increased frequency of M-MDSC, but not Treg cells, in the lungs. Using an adoptive transfer model, we confirmed that the effect of ArtC in the reduction in airway inflammation was dependent on M-MDSC. Altogether, our data show that ArtC exhibits an anti-inflammatory effect and might be an adjuvant therapy for allergic asthma.Núbia Sabrina MartinsThais Fernanda de Campos Fraga-SilvaGiseli Furlan CorreaMèdéton Mahoussi Michaël BokoLeandra Naira Zambelli RamalhoDébora Munhoz RodriguesJuliana Issa HoriDiego Luis CostaJairo Kenupp BastosVânia Luiza Deperon BonatoMDPI AGarticlepropolisartepillin Callergic asthmaM-MDSCtherapiesPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1763, p 1763 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	propolis artepillin C allergic asthma M-MDSC therapies Pharmacy and materia medica RS1-441
spellingShingle	propolis artepillin C allergic asthma M-MDSC therapies Pharmacy and materia medica RS1-441 Núbia Sabrina Martins Thais Fernanda de Campos Fraga-Silva Giseli Furlan Correa Mèdéton Mahoussi Michaël Boko Leandra Naira Zambelli Ramalho Débora Munhoz Rodrigues Juliana Issa Hori Diego Luis Costa Jairo Kenupp Bastos Vânia Luiza Deperon Bonato Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells
description	Propolis is a natural product produced by bees that is primarily used in complementary and alternative medicine and has anti-inflammatory, antibacterial, antiviral, and antitumoral biological properties. Some studies have reported the beneficial effects of propolis in models of allergic asthma. In a previous study, our group showed that green propolis treatment reduced airway inflammation and mucus secretion in an ovalbumin (OVA)-induced asthma model and resulted in increased regulatory T cells (Treg) and polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) frequencies in the lungs, two leukocyte populations that have immunosuppressive functions. In this study, we evaluated the anti-inflammatory effects of artepillin C (ArtC), the major compound of green propolis, in the context of allergic airway inflammation. Our results show that ArtC induces in vitro differentiation of Treg cells and monocytic MDSC (M-MDSC). Furthermore, in an OVA-induced asthma model, ArtC treatment reduced pulmonary inflammation, eosinophil influx to the airways, mucus and IL-5 secretion along with increased frequency of M-MDSC, but not Treg cells, in the lungs. Using an adoptive transfer model, we confirmed that the effect of ArtC in the reduction in airway inflammation was dependent on M-MDSC. Altogether, our data show that ArtC exhibits an anti-inflammatory effect and might be an adjuvant therapy for allergic asthma.
format	article
author	Núbia Sabrina Martins Thais Fernanda de Campos Fraga-Silva Giseli Furlan Correa Mèdéton Mahoussi Michaël Boko Leandra Naira Zambelli Ramalho Débora Munhoz Rodrigues Juliana Issa Hori Diego Luis Costa Jairo Kenupp Bastos Vânia Luiza Deperon Bonato
author_facet	Núbia Sabrina Martins Thais Fernanda de Campos Fraga-Silva Giseli Furlan Correa Mèdéton Mahoussi Michaël Boko Leandra Naira Zambelli Ramalho Débora Munhoz Rodrigues Juliana Issa Hori Diego Luis Costa Jairo Kenupp Bastos Vânia Luiza Deperon Bonato
author_sort	Núbia Sabrina Martins
title	Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells
title_short	Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells
title_full	Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells
title_fullStr	Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells
title_full_unstemmed	Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells
title_sort	artepillin c reduces allergic airway inflammation by induction of monocytic myeloid-derived suppressor cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5b61279df6a2467895f4249b3f26a362
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Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells

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