Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography

Scott M McClintic,1 Dae Yu Kim,2 Jeff Fingler,3 Susan Garcia,4 Robert J Zawadzki,4 Lawrence S Morse,4 Susanna S Park,4 Scott E Fraser,3 John S Werner,4 Jason P Ruggiero,5 Daniel M Schwartz6 1Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA; 2B...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	McClintic SM, Kim DY, Fingler J, Garcia S, Zawadzki RJ, Morse LS, Park SS, Fraser SE, Werner JS, Ruggiero JP, Schwartz DM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5b678691115a4d418de57baf3c374a43
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5b678691115a4d418de57baf3c374a43
record_format	dspace
spelling	oai:doaj.org-article:5b678691115a4d418de57baf3c374a432021-12-02T03:39:27ZDetection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography1177-5483https://doaj.org/article/5b678691115a4d418de57baf3c374a432015-07-01T00:00:00Zhttp://www.dovepress.com/detection-of-pigment-epithelial-detachment-vascularization-in-age-rela-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Scott M McClintic,1 Dae Yu Kim,2 Jeff Fingler,3 Susan Garcia,4 Robert J Zawadzki,4 Lawrence S Morse,4 Susanna S Park,4 Scott E Fraser,3 John S Werner,4 Jason P Ruggiero,5 Daniel M Schwartz6 1Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA; 2Beckman Laser Institute Korea and Department of Biomedical Engineering, Dankook University, Cheonan, South Korea; 3Translational Imaging Center, University of Southern California, Los Angeles, CA, 4Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, CA, 5Retina Associates, PC, Winchester, VA, 6Department of Ophthalmology and Vision Science, University of California San Francisco, San Francisco, CA, USA Purpose: To demonstrate the use of phase-variance optical coherence tomography (PV-OCT) angiography for detection of pigment epithelial detachment (PED) vascularization in age-related macular degeneration (AMD). Patients and methods: Patients with PEDs and exudative AMD were evaluated by the Retina Services at the University of California, Davis, and the University of California, San Francisco. Each subject underwent fluorescein angiography and structural optical coherence tomography (OCT). Phase-variance OCT analysis was used to create angiographic images of the retinal and choroidal vasculature. PV-OCT-generated B-scans were superimposed on structural OCT B-scans to allow easy identification of perfused vascular structures. Results: Three patients with vascularized PEDs were imaged with PV-OCT, and each was found to have a vascular signal extending from the choroid into the hyperreflective substance of the PED. Two patients who had no evidence of PED vascularization on fluorescein angiography did not have vascular signals within their PEDs on PV-OCT. Conclusion: Structural OCT and PV-OCT images can be combined to create composite B-scans that offer high-resolution views of the retinal tissue along with dynamic vascular visualization. This technique offers a fast, noninvasive method for detecting vascularization of PEDs in AMD and may aid in the early detection of neovascular disease. Keywords: OCT, imaging, retinaMcClintic SMKim DYFingler JGarcia SZawadzki RJMorse LSPark SSFraser SEWerner JSRuggiero JPSchwartz DMDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1299-1305 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 McClintic SM Kim DY Fingler J Garcia S Zawadzki RJ Morse LS Park SS Fraser SE Werner JS Ruggiero JP Schwartz DM Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography
description	Scott M McClintic,1 Dae Yu Kim,2 Jeff Fingler,3 Susan Garcia,4 Robert J Zawadzki,4 Lawrence S Morse,4 Susanna S Park,4 Scott E Fraser,3 John S Werner,4 Jason P Ruggiero,5 Daniel M Schwartz6 1Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA; 2Beckman Laser Institute Korea and Department of Biomedical Engineering, Dankook University, Cheonan, South Korea; 3Translational Imaging Center, University of Southern California, Los Angeles, CA, 4Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, CA, 5Retina Associates, PC, Winchester, VA, 6Department of Ophthalmology and Vision Science, University of California San Francisco, San Francisco, CA, USA Purpose: To demonstrate the use of phase-variance optical coherence tomography (PV-OCT) angiography for detection of pigment epithelial detachment (PED) vascularization in age-related macular degeneration (AMD). Patients and methods: Patients with PEDs and exudative AMD were evaluated by the Retina Services at the University of California, Davis, and the University of California, San Francisco. Each subject underwent fluorescein angiography and structural optical coherence tomography (OCT). Phase-variance OCT analysis was used to create angiographic images of the retinal and choroidal vasculature. PV-OCT-generated B-scans were superimposed on structural OCT B-scans to allow easy identification of perfused vascular structures. Results: Three patients with vascularized PEDs were imaged with PV-OCT, and each was found to have a vascular signal extending from the choroid into the hyperreflective substance of the PED. Two patients who had no evidence of PED vascularization on fluorescein angiography did not have vascular signals within their PEDs on PV-OCT. Conclusion: Structural OCT and PV-OCT images can be combined to create composite B-scans that offer high-resolution views of the retinal tissue along with dynamic vascular visualization. This technique offers a fast, noninvasive method for detecting vascularization of PEDs in AMD and may aid in the early detection of neovascular disease. Keywords: OCT, imaging, retina
format	article
author	McClintic SM Kim DY Fingler J Garcia S Zawadzki RJ Morse LS Park SS Fraser SE Werner JS Ruggiero JP Schwartz DM
author_facet	McClintic SM Kim DY Fingler J Garcia S Zawadzki RJ Morse LS Park SS Fraser SE Werner JS Ruggiero JP Schwartz DM
author_sort	McClintic SM
title	Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography
title_short	Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography
title_full	Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography
title_fullStr	Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography
title_full_unstemmed	Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography
title_sort	detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance oct angiography
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/5b678691115a4d418de57baf3c374a43
work_keys_str_mv	AT mcclinticsm detectionofpigmentepithelialdetachmentvascularizationinagerelatedmaculardegenerationusingphasevarianceoctangiography AT kimdy detectionofpigmentepithelialdetachmentvascularizationinagerelatedmaculardegenerationusingphasevarianceoctangiography AT finglerj detectionofpigmentepithelialdetachmentvascularizationinagerelatedmaculardegenerationusingphasevarianceoctangiography AT garcias detectionofpigmentepithelialdetachmentvascularizationinagerelatedmaculardegenerationusingphasevarianceoctangiography AT zawadzkirj detectionofpigmentepithelialdetachmentvascularizationinagerelatedmaculardegenerationusingphasevarianceoctangiography AT morsels detectionofpigmentepithelialdetachmentvascularizationinagerelatedmaculardegenerationusingphasevarianceoctangiography AT parkss detectionofpigmentepithelialdetachmentvascularizationinagerelatedmaculardegenerationusingphasevarianceoctangiography AT fraserse detectionofpigmentepithelialdetachmentvascularizationinagerelatedmaculardegenerationusingphasevarianceoctangiography AT wernerjs detectionofpigmentepithelialdetachmentvascularizationinagerelatedmaculardegenerationusingphasevarianceoctangiography AT ruggierojp detectionofpigmentepithelialdetachmentvascularizationinagerelatedmaculardegenerationusingphasevarianceoctangiography AT schwartzdm detectionofpigmentepithelialdetachmentvascularizationinagerelatedmaculardegenerationusingphasevarianceoctangiography
_version_	1718401663969001472

Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography

Ejemplares similares