Enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity

Abstract Morphological characteristics and source of adipose tissue as well as adipokines may increase cardiometabolic risk. This study aimed to explore whether adipose tissue characteristics may impact metabolic and atherogenic risks. Subcutaneous Adipose Tissue (SAT), Visceral Adipose Tissue (VAT)...

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Autores principales:	Juan Antonio Suárez-Cuenca, Gustavo De La Peña-Sosa, Karen De La Vega-Moreno, Diana Zaineff Banderas-Lares, Moisés Salamanca-García, José Enrique Martínez-Hernández, Eduardo Vera-Gómez, Alejandro Hernández-Patricio, Carlos Ramiro Zamora-Alemán, Gabriela Alexandra Domínguez-Pérez, Atzín Suá Ruíz-Hernández, Juan Ariel Gutiérrez-Buendía, Alberto Melchor-López, Moisés Ortíz-Fernández, Jesús Montoya-Ramírez, Omar Felipe Gaytán-Fuentes, Angélica Toríz-Ortíz, Mario Osorio-Valero, Julita Orozco-Vázquez, Sofía Lizeth Alcaráz-Estrada, Martha Eunice Rodríguez-Arellano, Brenda Maldonado-Arriaga, Rebeca Pérez-Cabeza de Vaca, Mónica Escamilla-Tilch, Juan Antonio Pineda-Juárez, Mario Antonio Téllez-González, Silvia García, Paul Mondragón-Terán
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5b6e9bd532124f5aa40be9ad552096bb
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spelling	oai:doaj.org-article:5b6e9bd532124f5aa40be9ad552096bb2021-12-02T15:23:29ZEnlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity10.1038/s41598-021-81289-22045-2322https://doaj.org/article/5b6e9bd532124f5aa40be9ad552096bb2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81289-2https://doaj.org/toc/2045-2322Abstract Morphological characteristics and source of adipose tissue as well as adipokines may increase cardiometabolic risk. This study aimed to explore whether adipose tissue characteristics may impact metabolic and atherogenic risks. Subcutaneous Adipose Tissue (SAT), Visceral Adipose Tissue (VAT) and peripheral blood were obtained from obese patients submitted to bariatric surgery. Adipose tissue (morphometry), plasma adiponectin, TNF-α, resistin (multiplexing) and biochemical chemistry were analyzed; as well as endothelial dysfunction (Flow Mediated Dilation, FMD) and atherogenesis (Carotid Intima Media Thickness, CIMT). Subgroups divided by adipocyte size and source were compared; as well as correlation and multivariate analysis. Sixty patients 36.6% males, aged 44 years-old, BMI 46.7 kg/m2 were included. SAT’s adipocytes showed a lower range of size expandability than VAT’s adipocytes. Independent from their source, larger adipocytes were associated with higher glucose, lower adiponectin and higher CIMT. Particularly, larger adipocytes from SAT were associated with higher blood pressure, lower insulin and HDL-cholesterol; and showed positive correlation with glucose, HbA1c, systolic/diastolic values, and negatively correlated with insulin and adiponectin. VAT’s larger adipocytes particularly associated with lower resistin and lower FMD values. Gender and Diabetes Mellitus significantly impacted the relation of adipocyte size/source with the metabolic and atherogenic risk. Multivariable analysis suggested hypertension-resistin-HbA1c interactions associated with SAT’s larger adipocytes; whereas potential insulin-adiponectin associations were observed for VAT’s larger adipocytes. Adipocyte morphology and source are differentially related with cardiometabolic and atherogenic risk in population with obesity, which are potentially affected by gender and Diabetes Mellitus.Juan Antonio Suárez-CuencaGustavo De La Peña-SosaKaren De La Vega-MorenoDiana Zaineff Banderas-LaresMoisés Salamanca-GarcíaJosé Enrique Martínez-HernándezEduardo Vera-GómezAlejandro Hernández-PatricioCarlos Ramiro Zamora-AlemánGabriela Alexandra Domínguez-PérezAtzín Suá Ruíz-HernándezJuan Ariel Gutiérrez-BuendíaAlberto Melchor-LópezMoisés Ortíz-FernándezJesús Montoya-RamírezOmar Felipe Gaytán-FuentesAngélica Toríz-OrtízMario Osorio-ValeroJulita Orozco-VázquezSofía Lizeth Alcaráz-EstradaMartha Eunice Rodríguez-ArellanoBrenda Maldonado-ArriagaRebeca Pérez-Cabeza de VacaMónica Escamilla-TilchJuan Antonio Pineda-JuárezMario Antonio Téllez-GonzálezSilvia GarcíaPaul Mondragón-TeránNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Antonio Suárez-Cuenca Gustavo De La Peña-Sosa Karen De La Vega-Moreno Diana Zaineff Banderas-Lares Moisés Salamanca-García José Enrique Martínez-Hernández Eduardo Vera-Gómez Alejandro Hernández-Patricio Carlos Ramiro Zamora-Alemán Gabriela Alexandra Domínguez-Pérez Atzín Suá Ruíz-Hernández Juan Ariel Gutiérrez-Buendía Alberto Melchor-López Moisés Ortíz-Fernández Jesús Montoya-Ramírez Omar Felipe Gaytán-Fuentes Angélica Toríz-Ortíz Mario Osorio-Valero Julita Orozco-Vázquez Sofía Lizeth Alcaráz-Estrada Martha Eunice Rodríguez-Arellano Brenda Maldonado-Arriaga Rebeca Pérez-Cabeza de Vaca Mónica Escamilla-Tilch Juan Antonio Pineda-Juárez Mario Antonio Téllez-González Silvia García Paul Mondragón-Terán Enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity
description	Abstract Morphological characteristics and source of adipose tissue as well as adipokines may increase cardiometabolic risk. This study aimed to explore whether adipose tissue characteristics may impact metabolic and atherogenic risks. Subcutaneous Adipose Tissue (SAT), Visceral Adipose Tissue (VAT) and peripheral blood were obtained from obese patients submitted to bariatric surgery. Adipose tissue (morphometry), plasma adiponectin, TNF-α, resistin (multiplexing) and biochemical chemistry were analyzed; as well as endothelial dysfunction (Flow Mediated Dilation, FMD) and atherogenesis (Carotid Intima Media Thickness, CIMT). Subgroups divided by adipocyte size and source were compared; as well as correlation and multivariate analysis. Sixty patients 36.6% males, aged 44 years-old, BMI 46.7 kg/m2 were included. SAT’s adipocytes showed a lower range of size expandability than VAT’s adipocytes. Independent from their source, larger adipocytes were associated with higher glucose, lower adiponectin and higher CIMT. Particularly, larger adipocytes from SAT were associated with higher blood pressure, lower insulin and HDL-cholesterol; and showed positive correlation with glucose, HbA1c, systolic/diastolic values, and negatively correlated with insulin and adiponectin. VAT’s larger adipocytes particularly associated with lower resistin and lower FMD values. Gender and Diabetes Mellitus significantly impacted the relation of adipocyte size/source with the metabolic and atherogenic risk. Multivariable analysis suggested hypertension-resistin-HbA1c interactions associated with SAT’s larger adipocytes; whereas potential insulin-adiponectin associations were observed for VAT’s larger adipocytes. Adipocyte morphology and source are differentially related with cardiometabolic and atherogenic risk in population with obesity, which are potentially affected by gender and Diabetes Mellitus.
format	article
author	Juan Antonio Suárez-Cuenca Gustavo De La Peña-Sosa Karen De La Vega-Moreno Diana Zaineff Banderas-Lares Moisés Salamanca-García José Enrique Martínez-Hernández Eduardo Vera-Gómez Alejandro Hernández-Patricio Carlos Ramiro Zamora-Alemán Gabriela Alexandra Domínguez-Pérez Atzín Suá Ruíz-Hernández Juan Ariel Gutiérrez-Buendía Alberto Melchor-López Moisés Ortíz-Fernández Jesús Montoya-Ramírez Omar Felipe Gaytán-Fuentes Angélica Toríz-Ortíz Mario Osorio-Valero Julita Orozco-Vázquez Sofía Lizeth Alcaráz-Estrada Martha Eunice Rodríguez-Arellano Brenda Maldonado-Arriaga Rebeca Pérez-Cabeza de Vaca Mónica Escamilla-Tilch Juan Antonio Pineda-Juárez Mario Antonio Téllez-González Silvia García Paul Mondragón-Terán
author_facet	Juan Antonio Suárez-Cuenca Gustavo De La Peña-Sosa Karen De La Vega-Moreno Diana Zaineff Banderas-Lares Moisés Salamanca-García José Enrique Martínez-Hernández Eduardo Vera-Gómez Alejandro Hernández-Patricio Carlos Ramiro Zamora-Alemán Gabriela Alexandra Domínguez-Pérez Atzín Suá Ruíz-Hernández Juan Ariel Gutiérrez-Buendía Alberto Melchor-López Moisés Ortíz-Fernández Jesús Montoya-Ramírez Omar Felipe Gaytán-Fuentes Angélica Toríz-Ortíz Mario Osorio-Valero Julita Orozco-Vázquez Sofía Lizeth Alcaráz-Estrada Martha Eunice Rodríguez-Arellano Brenda Maldonado-Arriaga Rebeca Pérez-Cabeza de Vaca Mónica Escamilla-Tilch Juan Antonio Pineda-Juárez Mario Antonio Téllez-González Silvia García Paul Mondragón-Terán
author_sort	Juan Antonio Suárez-Cuenca
title	Enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity
title_short	Enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity
title_full	Enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity
title_fullStr	Enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity
title_full_unstemmed	Enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity
title_sort	enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b6e9bd532124f5aa40be9ad552096bb
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Enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity

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