Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease
Angelika Bielach-Bazyluk,1 Edyta Zbroch,2 Katarzyna Czajkowska,1 Ewa Koc-Zorawska,1 Katarzyna Kakareko,1 Alicja Rydzewska-Rosolowska,1 Tomasz Hryszko1 1 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University, Bialystok, Poland; 2Department of Internal Medicine and Hyp...
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Dove Medical Press
2021
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oai:doaj.org-article:5b6f01a7a4a046239f627311374a4f702021-12-02T11:45:09ZSerum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease1178-1998https://doaj.org/article/5b6f01a7a4a046239f627311374a4f702021-03-01T00:00:00Zhttps://www.dovepress.com/serum-sirtuin-1nbspis-independently-associated-with-intact-pth-among-p-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Angelika Bielach-Bazyluk,1 Edyta Zbroch,2 Katarzyna Czajkowska,1 Ewa Koc-Zorawska,1 Katarzyna Kakareko,1 Alicja Rydzewska-Rosolowska,1 Tomasz Hryszko1 1 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University, Bialystok, Poland; 2Department of Internal Medicine and Hypertension, Medical University, Bialystok, PolandCorrespondence: Angelika Bielach-Bazyluk 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University, Sklodowskiej – Curie 24a, Bialystok, 15-276, PolandTel +48 858317872Email b.angelika@wp.plBackground: Sirtuin 1 is involved in the pathogenesis of age-related diseases.Purpose: The aim of the study was to assess the clinical and diagnostic value of serum sirtuin 1 concentration in patients with CKD.Patients and Methods: The serum sirtuin 1 level was evaluated using ELISA kit in 100 CKD patients stratified for five stages and in a control group of 24 healthy volunteers.Results: Serum sirtuin 1 concentration was higher in the CKD group compared with the control group (p< 0.05). Sirtuin 1 correlated with conventional CKD biomarkers and eGFR equations, intact parathyroid hormone (iPTH) and age (all p< 0.05). Statins, AT1 receptor antagonists and β-blockers use were associated with decreased sirtuin concentration (p< 0.05). Sirtuin 1 was able to distinguish CKD from control group with high sensitivity and specificity (93% and 87%, respectively; AUC=0.954). Surprisingly, after adjustment only iPTH concentration was an independent predictor of sirtuin 1 level.Conclusion: The association between sirtuin 1, eGFR equations and iPTH indicates its possible usefulness as a kidney function marker. In terms of iPTH being the only independent predictor of circulating sirtuin 1 it can be considered as an indirect cardiovascular risk biomarker regardless of renal function and provide additional information for patient management. Alternatively, sirtuin 1 is recognized as protective against vascular disease, and we demonstrated a positive correlation with iPTH, which may be related to accumulation of (7-84)-PTH having opposite biological effects to full-length PTH. Further studies are needed to explore the interplay between sirtuin 1, PTH and CKD-related vascular calcification as well as to assess its prognostic value in observational studies.Keywords: sirtuin 1, SIRT1, CKD, chronic kidney disease, parathyroid hormone, PTHBielach-Bazyluk AZbroch ECzajkowska KKoc-Zorawska EKakareko KRydzewska-Rosolowska AHryszko TDove Medical Pressarticlesirtuin 1sirt1ckdchronic kidney diseaseparathyroid hormonepthGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 525-536 (2021) |
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sirtuin 1 sirt1 ckd chronic kidney disease parathyroid hormone pth Geriatrics RC952-954.6 |
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sirtuin 1 sirt1 ckd chronic kidney disease parathyroid hormone pth Geriatrics RC952-954.6 Bielach-Bazyluk A Zbroch E Czajkowska K Koc-Zorawska E Kakareko K Rydzewska-Rosolowska A Hryszko T Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease |
| description |
Angelika Bielach-Bazyluk,1 Edyta Zbroch,2 Katarzyna Czajkowska,1 Ewa Koc-Zorawska,1 Katarzyna Kakareko,1 Alicja Rydzewska-Rosolowska,1 Tomasz Hryszko1 1 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University, Bialystok, Poland; 2Department of Internal Medicine and Hypertension, Medical University, Bialystok, PolandCorrespondence: Angelika Bielach-Bazyluk 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University, Sklodowskiej – Curie 24a, Bialystok, 15-276, PolandTel +48 858317872Email b.angelika@wp.plBackground: Sirtuin 1 is involved in the pathogenesis of age-related diseases.Purpose: The aim of the study was to assess the clinical and diagnostic value of serum sirtuin 1 concentration in patients with CKD.Patients and Methods: The serum sirtuin 1 level was evaluated using ELISA kit in 100 CKD patients stratified for five stages and in a control group of 24 healthy volunteers.Results: Serum sirtuin 1 concentration was higher in the CKD group compared with the control group (p< 0.05). Sirtuin 1 correlated with conventional CKD biomarkers and eGFR equations, intact parathyroid hormone (iPTH) and age (all p< 0.05). Statins, AT1 receptor antagonists and β-blockers use were associated with decreased sirtuin concentration (p< 0.05). Sirtuin 1 was able to distinguish CKD from control group with high sensitivity and specificity (93% and 87%, respectively; AUC=0.954). Surprisingly, after adjustment only iPTH concentration was an independent predictor of sirtuin 1 level.Conclusion: The association between sirtuin 1, eGFR equations and iPTH indicates its possible usefulness as a kidney function marker. In terms of iPTH being the only independent predictor of circulating sirtuin 1 it can be considered as an indirect cardiovascular risk biomarker regardless of renal function and provide additional information for patient management. Alternatively, sirtuin 1 is recognized as protective against vascular disease, and we demonstrated a positive correlation with iPTH, which may be related to accumulation of (7-84)-PTH having opposite biological effects to full-length PTH. Further studies are needed to explore the interplay between sirtuin 1, PTH and CKD-related vascular calcification as well as to assess its prognostic value in observational studies.Keywords: sirtuin 1, SIRT1, CKD, chronic kidney disease, parathyroid hormone, PTH |
| format |
article |
| author |
Bielach-Bazyluk A Zbroch E Czajkowska K Koc-Zorawska E Kakareko K Rydzewska-Rosolowska A Hryszko T |
| author_facet |
Bielach-Bazyluk A Zbroch E Czajkowska K Koc-Zorawska E Kakareko K Rydzewska-Rosolowska A Hryszko T |
| author_sort |
Bielach-Bazyluk A |
| title |
Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease |
| title_short |
Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease |
| title_full |
Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease |
| title_fullStr |
Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease |
| title_full_unstemmed |
Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease |
| title_sort |
serum sirtuin 1 is independently associated with intact pth among patients with chronic kidney disease |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/5b6f01a7a4a046239f627311374a4f70 |
| work_keys_str_mv |
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| _version_ |
1718395282513723392 |