Recent strategies for enhancing the therapeutic efficacy of stem cells in wound healing

Abstract Skin wound healing is a multi-stage process that depends on the coordination of multiple cells and mediators. Chronic or non-healing wounds resulting from the dysregulation of this process represent a challenge for the healthcare system. For skin wound management, there are various approach...

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Autores principales:	Yongqing Zhao, Min Wang, Feng Liang, Jiannan Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Wound healing Embryonic stem cells Adult stem cells Induced pluripotent stem cells Mesenchymal stem cells Medicine (General) R5-920 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/5b702522e58140ca86433da2f4452de2
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spelling	oai:doaj.org-article:5b702522e58140ca86433da2f4452de22021-11-28T12:06:28ZRecent strategies for enhancing the therapeutic efficacy of stem cells in wound healing10.1186/s13287-021-02657-31757-6512https://doaj.org/article/5b702522e58140ca86433da2f4452de22021-11-01T00:00:00Zhttps://doi.org/10.1186/s13287-021-02657-3https://doaj.org/toc/1757-6512Abstract Skin wound healing is a multi-stage process that depends on the coordination of multiple cells and mediators. Chronic or non-healing wounds resulting from the dysregulation of this process represent a challenge for the healthcare system. For skin wound management, there are various approaches to tissue recovery. For decades, stem cell therapy has made outstanding achievements in wound regeneration. Three major types of stem cells, including embryonic stem cells, adult stem cells, and induced pluripotent stem cells, have been explored intensely. Mostly, mesenchymal stem cells are thought to be an extensive cell type for tissue repair. However, the limited cell efficacy and the underutilized therapeutic potential remain to be addressed. Exploring novel and advanced treatments to enhance stem cell efficacy is an urgent need. Diverse strategies are applied to maintain cell survival and increase cell functionality. In this study, we outline current approaches aiming to improve the beneficial outcomes of cell therapy to better grasp clinical cell transformation.Yongqing ZhaoMin WangFeng LiangJiannan LiBMCarticleWound healingEmbryonic stem cellsAdult stem cellsInduced pluripotent stem cellsMesenchymal stem cellsMedicine (General)R5-920BiochemistryQD415-436ENStem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Wound healing Embryonic stem cells Adult stem cells Induced pluripotent stem cells Mesenchymal stem cells Medicine (General) R5-920 Biochemistry QD415-436
spellingShingle	Wound healing Embryonic stem cells Adult stem cells Induced pluripotent stem cells Mesenchymal stem cells Medicine (General) R5-920 Biochemistry QD415-436 Yongqing Zhao Min Wang Feng Liang Jiannan Li Recent strategies for enhancing the therapeutic efficacy of stem cells in wound healing
description	Abstract Skin wound healing is a multi-stage process that depends on the coordination of multiple cells and mediators. Chronic or non-healing wounds resulting from the dysregulation of this process represent a challenge for the healthcare system. For skin wound management, there are various approaches to tissue recovery. For decades, stem cell therapy has made outstanding achievements in wound regeneration. Three major types of stem cells, including embryonic stem cells, adult stem cells, and induced pluripotent stem cells, have been explored intensely. Mostly, mesenchymal stem cells are thought to be an extensive cell type for tissue repair. However, the limited cell efficacy and the underutilized therapeutic potential remain to be addressed. Exploring novel and advanced treatments to enhance stem cell efficacy is an urgent need. Diverse strategies are applied to maintain cell survival and increase cell functionality. In this study, we outline current approaches aiming to improve the beneficial outcomes of cell therapy to better grasp clinical cell transformation.
format	article
author	Yongqing Zhao Min Wang Feng Liang Jiannan Li
author_facet	Yongqing Zhao Min Wang Feng Liang Jiannan Li
author_sort	Yongqing Zhao
title	Recent strategies for enhancing the therapeutic efficacy of stem cells in wound healing
title_short	Recent strategies for enhancing the therapeutic efficacy of stem cells in wound healing
title_full	Recent strategies for enhancing the therapeutic efficacy of stem cells in wound healing
title_fullStr	Recent strategies for enhancing the therapeutic efficacy of stem cells in wound healing
title_full_unstemmed	Recent strategies for enhancing the therapeutic efficacy of stem cells in wound healing
title_sort	recent strategies for enhancing the therapeutic efficacy of stem cells in wound healing
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5b702522e58140ca86433da2f4452de2
work_keys_str_mv	AT yongqingzhao recentstrategiesforenhancingthetherapeuticefficacyofstemcellsinwoundhealing AT minwang recentstrategiesforenhancingthetherapeuticefficacyofstemcellsinwoundhealing AT fengliang recentstrategiesforenhancingthetherapeuticefficacyofstemcellsinwoundhealing AT jiannanli recentstrategiesforenhancingthetherapeuticefficacyofstemcellsinwoundhealing
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Recent strategies for enhancing the therapeutic efficacy of stem cells in wound healing

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