CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

Stabilization of DNA quadruplex structures (G4) is lethal for cells with a compromised DNA repair pathway. Here, the authors show that CX-5461, a small molecule in clinical trials as RNA polymerase inhibitor, has G4-stablization properties and can be repurposed to target DNA repair-defective cancers...

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Autores principales:	Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J. O’Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia, Farhia Kabeer, Daniel Lai, Priscilla Soriano, Judit Banáth, Derek S. Chiu, Damian Yap, Daniel D. Le, Frank B. Ye, Anni Zhang, Kelsie Thu, John Soong, Shu-chuan Lin, Angela Hsin Chin Tsai, Tomo Osako, Teresa Algara, Darren N. Saunders, Jason Wong, Jian Xian, Marcel B. Bally, James D. Brenton, Grant W. Brown, Sohrab P. Shah, David Cescon, Tak W. Mak, Carlos Caldas, Peter C. Stirling, Phil Hieter, Shankar Balasubramanian, Samuel Aparicio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b722e62084b4032919682ab16257e1a
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spelling	oai:doaj.org-article:5b722e62084b4032919682ab16257e1a2021-12-02T15:37:04ZCX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours10.1038/ncomms144322041-1723https://doaj.org/article/5b722e62084b4032919682ab16257e1a2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14432https://doaj.org/toc/2041-1723Stabilization of DNA quadruplex structures (G4) is lethal for cells with a compromised DNA repair pathway. Here, the authors show that CX-5461, a small molecule in clinical trials as RNA polymerase inhibitor, has G4-stablization properties and can be repurposed to target DNA repair-defective cancers cells.Hong XuMarco Di AntonioSteven McKinneyVeena MathewBrandon HoNigel J. O’NeilNancy Dos SantosJennifer SilvesterVivien WeiJessica GarciaFarhia KabeerDaniel LaiPriscilla SorianoJudit BanáthDerek S. ChiuDamian YapDaniel D. LeFrank B. YeAnni ZhangKelsie ThuJohn SoongShu-chuan LinAngela Hsin Chin TsaiTomo OsakoTeresa AlgaraDarren N. SaundersJason WongJian XianMarcel B. BallyJames D. BrentonGrant W. BrownSohrab P. ShahDavid CesconTak W. MakCarlos CaldasPeter C. StirlingPhil HieterShankar BalasubramanianSamuel AparicioNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hong Xu Marco Di Antonio Steven McKinney Veena Mathew Brandon Ho Nigel J. O’Neil Nancy Dos Santos Jennifer Silvester Vivien Wei Jessica Garcia Farhia Kabeer Daniel Lai Priscilla Soriano Judit Banáth Derek S. Chiu Damian Yap Daniel D. Le Frank B. Ye Anni Zhang Kelsie Thu John Soong Shu-chuan Lin Angela Hsin Chin Tsai Tomo Osako Teresa Algara Darren N. Saunders Jason Wong Jian Xian Marcel B. Bally James D. Brenton Grant W. Brown Sohrab P. Shah David Cescon Tak W. Mak Carlos Caldas Peter C. Stirling Phil Hieter Shankar Balasubramanian Samuel Aparicio CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
description	Stabilization of DNA quadruplex structures (G4) is lethal for cells with a compromised DNA repair pathway. Here, the authors show that CX-5461, a small molecule in clinical trials as RNA polymerase inhibitor, has G4-stablization properties and can be repurposed to target DNA repair-defective cancers cells.
format	article
author	Hong Xu Marco Di Antonio Steven McKinney Veena Mathew Brandon Ho Nigel J. O’Neil Nancy Dos Santos Jennifer Silvester Vivien Wei Jessica Garcia Farhia Kabeer Daniel Lai Priscilla Soriano Judit Banáth Derek S. Chiu Damian Yap Daniel D. Le Frank B. Ye Anni Zhang Kelsie Thu John Soong Shu-chuan Lin Angela Hsin Chin Tsai Tomo Osako Teresa Algara Darren N. Saunders Jason Wong Jian Xian Marcel B. Bally James D. Brenton Grant W. Brown Sohrab P. Shah David Cescon Tak W. Mak Carlos Caldas Peter C. Stirling Phil Hieter Shankar Balasubramanian Samuel Aparicio
author_facet	Hong Xu Marco Di Antonio Steven McKinney Veena Mathew Brandon Ho Nigel J. O’Neil Nancy Dos Santos Jennifer Silvester Vivien Wei Jessica Garcia Farhia Kabeer Daniel Lai Priscilla Soriano Judit Banáth Derek S. Chiu Damian Yap Daniel D. Le Frank B. Ye Anni Zhang Kelsie Thu John Soong Shu-chuan Lin Angela Hsin Chin Tsai Tomo Osako Teresa Algara Darren N. Saunders Jason Wong Jian Xian Marcel B. Bally James D. Brenton Grant W. Brown Sohrab P. Shah David Cescon Tak W. Mak Carlos Caldas Peter C. Stirling Phil Hieter Shankar Balasubramanian Samuel Aparicio
author_sort	Hong Xu
title	CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
title_short	CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
title_full	CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
title_fullStr	CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
title_full_unstemmed	CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
title_sort	cx-5461 is a dna g-quadruplex stabilizer with selective lethality in brca1/2 deficient tumours
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5b722e62084b4032919682ab16257e1a
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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

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