Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers

Synthetic mimics of glycoproteins and proteoglycans have wide applications in biomedicine, yet preparation has been challenged by their high grafting and glycosylation densities. Here the authors show one-pot dual-catalysis polymerization of glycan-bearing α-amino acid N-carboxyanhydrides to form gl...

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Autores principales:	Zachary S. Clauss, Casia L. Wardzala, Austin E. Schlirf, Nathaniel S. Wright, Simranpreet S. Saini, Bibiana Onoa, Carlos Bustamante, Jessica R. Kramer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b77b5d064be4c76a8a641d34508d0c7
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spelling	oai:doaj.org-article:5b77b5d064be4c76a8a641d34508d0c72021-11-14T12:34:59ZTunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers10.1038/s41467-021-26808-52041-1723https://doaj.org/article/5b77b5d064be4c76a8a641d34508d0c72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26808-5https://doaj.org/toc/2041-1723Synthetic mimics of glycoproteins and proteoglycans have wide applications in biomedicine, yet preparation has been challenged by their high grafting and glycosylation densities. Here the authors show one-pot dual-catalysis polymerization of glycan-bearing α-amino acid N-carboxyanhydrides to form glycopolypeptide brushes.Zachary S. ClaussCasia L. WardzalaAustin E. SchlirfNathaniel S. WrightSimranpreet S. SainiBibiana OnoaCarlos BustamanteJessica R. KramerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zachary S. Clauss Casia L. Wardzala Austin E. Schlirf Nathaniel S. Wright Simranpreet S. Saini Bibiana Onoa Carlos Bustamante Jessica R. Kramer Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers
description	Synthetic mimics of glycoproteins and proteoglycans have wide applications in biomedicine, yet preparation has been challenged by their high grafting and glycosylation densities. Here the authors show one-pot dual-catalysis polymerization of glycan-bearing α-amino acid N-carboxyanhydrides to form glycopolypeptide brushes.
format	article
author	Zachary S. Clauss Casia L. Wardzala Austin E. Schlirf Nathaniel S. Wright Simranpreet S. Saini Bibiana Onoa Carlos Bustamante Jessica R. Kramer
author_facet	Zachary S. Clauss Casia L. Wardzala Austin E. Schlirf Nathaniel S. Wright Simranpreet S. Saini Bibiana Onoa Carlos Bustamante Jessica R. Kramer
author_sort	Zachary S. Clauss
title	Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers
title_short	Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers
title_full	Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers
title_fullStr	Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers
title_full_unstemmed	Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers
title_sort	tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b77b5d064be4c76a8a641d34508d0c7
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Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers

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