Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variants against cardiometabolic and immune phenotypes.
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Nature Portfolio
2018
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oai:doaj.org-article:5b782df960c64245a2f0b6bdfadd77452021-12-02T15:33:37ZAnalysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease10.1038/s41467-018-03911-82041-1723https://doaj.org/article/5b782df960c64245a2f0b6bdfadd77452018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03911-8https://doaj.org/toc/2041-1723Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variants against cardiometabolic and immune phenotypes.Connor A. EmdinAmit V. KheraMark ChaffinDerek KlarinPradeep NatarajanKrishna AragamMary HaasAlexander BickSeyedeh M. ZekavatAkihiro NomuraDiego ArdissinoJames G. WilsonHeribert SchunkertRuth McPhersonHugh WatkinsRoberto ElosuaMatthew J. BownNilesh J. SamaniUsman BaberJeanette ErdmannNamrata GuptaJohn DaneshDaniel ChasmanPaul RidkerJoshua DennyLisa BastaracheJudith H. LichtmanGail D’OnofrioJennifer MatteraJohn A. SpertusWayne H.-H. SheuKent D. TaylorBruce M. PsatyStephen S. RichWendy PostJerome I. RotterYii-Der Ida ChenHarlan KrumholzDanish SaleheenStacey GabrielSekar KathiresanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
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Science Q |
| spellingShingle |
Science Q Connor A. Emdin Amit V. Khera Mark Chaffin Derek Klarin Pradeep Natarajan Krishna Aragam Mary Haas Alexander Bick Seyedeh M. Zekavat Akihiro Nomura Diego Ardissino James G. Wilson Heribert Schunkert Ruth McPherson Hugh Watkins Roberto Elosua Matthew J. Bown Nilesh J. Samani Usman Baber Jeanette Erdmann Namrata Gupta John Danesh Daniel Chasman Paul Ridker Joshua Denny Lisa Bastarache Judith H. Lichtman Gail D’Onofrio Jennifer Mattera John A. Spertus Wayne H.-H. Sheu Kent D. Taylor Bruce M. Psaty Stephen S. Rich Wendy Post Jerome I. Rotter Yii-Der Ida Chen Harlan Krumholz Danish Saleheen Stacey Gabriel Sekar Kathiresan Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease |
| description |
Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variants against cardiometabolic and immune phenotypes. |
| format |
article |
| author |
Connor A. Emdin Amit V. Khera Mark Chaffin Derek Klarin Pradeep Natarajan Krishna Aragam Mary Haas Alexander Bick Seyedeh M. Zekavat Akihiro Nomura Diego Ardissino James G. Wilson Heribert Schunkert Ruth McPherson Hugh Watkins Roberto Elosua Matthew J. Bown Nilesh J. Samani Usman Baber Jeanette Erdmann Namrata Gupta John Danesh Daniel Chasman Paul Ridker Joshua Denny Lisa Bastarache Judith H. Lichtman Gail D’Onofrio Jennifer Mattera John A. Spertus Wayne H.-H. Sheu Kent D. Taylor Bruce M. Psaty Stephen S. Rich Wendy Post Jerome I. Rotter Yii-Der Ida Chen Harlan Krumholz Danish Saleheen Stacey Gabriel Sekar Kathiresan |
| author_facet |
Connor A. Emdin Amit V. Khera Mark Chaffin Derek Klarin Pradeep Natarajan Krishna Aragam Mary Haas Alexander Bick Seyedeh M. Zekavat Akihiro Nomura Diego Ardissino James G. Wilson Heribert Schunkert Ruth McPherson Hugh Watkins Roberto Elosua Matthew J. Bown Nilesh J. Samani Usman Baber Jeanette Erdmann Namrata Gupta John Danesh Daniel Chasman Paul Ridker Joshua Denny Lisa Bastarache Judith H. Lichtman Gail D’Onofrio Jennifer Mattera John A. Spertus Wayne H.-H. Sheu Kent D. Taylor Bruce M. Psaty Stephen S. Rich Wendy Post Jerome I. Rotter Yii-Der Ida Chen Harlan Krumholz Danish Saleheen Stacey Gabriel Sekar Kathiresan |
| author_sort |
Connor A. Emdin |
| title |
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease |
| title_short |
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease |
| title_full |
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease |
| title_fullStr |
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease |
| title_full_unstemmed |
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease |
| title_sort |
analysis of predicted loss-of-function variants in uk biobank identifies variants protective for disease |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/5b782df960c64245a2f0b6bdfadd7745 |
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