Cytosolic protein delivery using pH-responsive, charge-reversible lipid nanoparticles

Abstract Although proteins have attractive features as biopharmaceuticals, the difficulty in delivering them into the cell interior limits their applicability. Lipid nanoparticles (LNPs) are a promising class of delivery vehicles. When designing a protein delivery system based on LNPs, the major cha...

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Autores principales: Yusuke Hirai, Hisaaki Hirose, Miki Imanishi, Tomohiro Asai, Shiroh Futaki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5b79394d705e4bc08ba13993b49b0bac
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