Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus

The extent of damage to the nervous, vascular and microcirculatory systems in diabetic patients determine the regulation of physiological events that lead to the formation of chronic wounds, reduction of patient quality of life and increase of the financial value of medical care. Successful physiolo...

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Autores principales:	Ekaterina Viktorovna Artemova, Anna Maksimovna Gorbacheva, Gagik Radikovich Galstyan, Alla Yur'evna Tokmakova, Svetlana Anatol'evna Gavrilova, Ivan Ivanovich Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2016
Materias:	diabetes mellitus keratinocytes chronic wounds diabetic foot neuroregulation adrenoreceptors cholinoreceptors Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/5b7afcebea3846418fb543caf748dadd
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spelling	oai:doaj.org-article:5b7afcebea3846418fb543caf748dadd2021-11-14T09:00:20ZNeurohumoral mechanisms of keratinocytes regulation in diabetes mellitus2072-03512072-037810.14341/DM8131https://doaj.org/article/5b7afcebea3846418fb543caf748dadd2016-11-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8131https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The extent of damage to the nervous, vascular and microcirculatory systems in diabetic patients determine the regulation of physiological events that lead to the formation of chronic wounds, reduction of patient quality of life and increase of the financial value of medical care. Successful physiological repair is impossible without the successive phases of inflammation, proliferation and wound healing. Keratinocytes are the major cellular barrier components of the epidermis. These cells play an important role in physiological repair, as suggested by recent research, with many cells able to secrete steroid hormones de novo. Damage to the integrity of the skin leads to keratinocyte activation, triggering a cascade of reactions that contribute to changes in epidermal cell phenotype and lead to their proliferation and migration, analogous to changes in cellular adhesion and configuration of the cytoskeleton. An open question remains as to how the keratinocyte cell cycle, which is altered under conditions of hyperglycemia, and neurotransmitter metabolism during different stages of physiological repair are regulated. Understanding these processes will provide a scientific basis for the development of new targets for pharmacotherapies.Ekaterina Viktorovna ArtemovaAnna Maksimovna GorbachevaGagik Radikovich GalstyanAlla Yur'evna TokmakovaSvetlana Anatol'evna GavrilovaIvan Ivanovich DedovEndocrinology Research Centrearticlediabetes mellituskeratinocyteschronic woundsdiabetic footneuroregulationadrenoreceptorscholinoreceptorsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 19, Iss 5, Pp 366-374 (2016)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus keratinocytes chronic wounds diabetic foot neuroregulation adrenoreceptors cholinoreceptors Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus keratinocytes chronic wounds diabetic foot neuroregulation adrenoreceptors cholinoreceptors Nutritional diseases. Deficiency diseases RC620-627 Ekaterina Viktorovna Artemova Anna Maksimovna Gorbacheva Gagik Radikovich Galstyan Alla Yur'evna Tokmakova Svetlana Anatol'evna Gavrilova Ivan Ivanovich Dedov Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus
description	The extent of damage to the nervous, vascular and microcirculatory systems in diabetic patients determine the regulation of physiological events that lead to the formation of chronic wounds, reduction of patient quality of life and increase of the financial value of medical care. Successful physiological repair is impossible without the successive phases of inflammation, proliferation and wound healing. Keratinocytes are the major cellular barrier components of the epidermis. These cells play an important role in physiological repair, as suggested by recent research, with many cells able to secrete steroid hormones de novo. Damage to the integrity of the skin leads to keratinocyte activation, triggering a cascade of reactions that contribute to changes in epidermal cell phenotype and lead to their proliferation and migration, analogous to changes in cellular adhesion and configuration of the cytoskeleton. An open question remains as to how the keratinocyte cell cycle, which is altered under conditions of hyperglycemia, and neurotransmitter metabolism during different stages of physiological repair are regulated. Understanding these processes will provide a scientific basis for the development of new targets for pharmacotherapies.
format	article
author	Ekaterina Viktorovna Artemova Anna Maksimovna Gorbacheva Gagik Radikovich Galstyan Alla Yur'evna Tokmakova Svetlana Anatol'evna Gavrilova Ivan Ivanovich Dedov
author_facet	Ekaterina Viktorovna Artemova Anna Maksimovna Gorbacheva Gagik Radikovich Galstyan Alla Yur'evna Tokmakova Svetlana Anatol'evna Gavrilova Ivan Ivanovich Dedov
author_sort	Ekaterina Viktorovna Artemova
title	Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus
title_short	Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus
title_full	Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus
title_fullStr	Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus
title_full_unstemmed	Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus
title_sort	neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2016
url	https://doaj.org/article/5b7afcebea3846418fb543caf748dadd
work_keys_str_mv	AT ekaterinaviktorovnaartemova neurohumoralmechanismsofkeratinocytesregulationindiabetesmellitus AT annamaksimovnagorbacheva neurohumoralmechanismsofkeratinocytesregulationindiabetesmellitus AT gagikradikovichgalstyan neurohumoralmechanismsofkeratinocytesregulationindiabetesmellitus AT allayurevnatokmakova neurohumoralmechanismsofkeratinocytesregulationindiabetesmellitus AT svetlanaanatolevnagavrilova neurohumoralmechanismsofkeratinocytesregulationindiabetesmellitus AT ivanivanovichdedov neurohumoralmechanismsofkeratinocytesregulationindiabetesmellitus
_version_	1718429529013223424

Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus

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