Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response

Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response

Parkinson’s disease (PD) is a prevalent movement disorder characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). The 6-hydroxydopamine (6-OHDA) lesion is still one of the most widely used techniques for modeling Parkinson’s disease (PD) in rodents. De...

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Main Authors: Bárbara Mendes-Pinheiro, Carina Soares-Cunha, Ana Marote, Eduardo Loureiro-Campos, Jonas Campos, Sandra Barata-Antunes, Daniela Monteiro-Fernandes, Diogo Santos, Sara Duarte-Silva, Luísa Pinto, António José Salgado
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
Parkinson’s disease
6-OHDA
unilateral
striatum
dopaminergic degeneration
motor behavior
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/5b7bfaea66c64604aa2a882f0e19aabe
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https://doaj.org/article/5b7bfaea66c64604aa2a882f0e19aabe

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