A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
Antibodies that block the Wnt inhibitors sclerostin and DKK- 1 enhance bone formation and fracture repair. Here the authors show these monospecific antibodies induce compensatory mechanisms that limit efficacy, and have designed a sclerostin/DKK-1 bispecific antibody that promotes superior fracture...
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Nature Portfolio
2016
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oai:doaj.org-article:5b80b8c1d296447f878d119b9b8140cb2021-12-02T17:33:20ZA bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair10.1038/ncomms115052041-1723https://doaj.org/article/5b80b8c1d296447f878d119b9b8140cb2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11505https://doaj.org/toc/2041-1723Antibodies that block the Wnt inhibitors sclerostin and DKK- 1 enhance bone formation and fracture repair. Here the authors show these monospecific antibodies induce compensatory mechanisms that limit efficacy, and have designed a sclerostin/DKK-1 bispecific antibody that promotes superior fracture repair in rodents and bone formation in primates.Monica FlorioKannan GunasekaranMarina StolinaXiaodong LiLing LiuBarbara TiptonHossein Salimi-MoosaviFranklin J. AsuncionChaoyang LiBanghua SunHong Lin TanLi ZhangChun-Ya HanRyan CaseAmy N. DuguayMario GrisantiJennitte StevensJames K. PretoriusEfrain PachecoHeidi JonesQing ChenBrian D. SorianoJie WenBrenda HeronFrederick W. JacobsenEmil BrisanWilliam G. RichardsHua Zhu KeMichael S. OminskyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
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Science Q |
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Science Q Monica Florio Kannan Gunasekaran Marina Stolina Xiaodong Li Ling Liu Barbara Tipton Hossein Salimi-Moosavi Franklin J. Asuncion Chaoyang Li Banghua Sun Hong Lin Tan Li Zhang Chun-Ya Han Ryan Case Amy N. Duguay Mario Grisanti Jennitte Stevens James K. Pretorius Efrain Pacheco Heidi Jones Qing Chen Brian D. Soriano Jie Wen Brenda Heron Frederick W. Jacobsen Emil Brisan William G. Richards Hua Zhu Ke Michael S. Ominsky A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair |
| description |
Antibodies that block the Wnt inhibitors sclerostin and DKK- 1 enhance bone formation and fracture repair. Here the authors show these monospecific antibodies induce compensatory mechanisms that limit efficacy, and have designed a sclerostin/DKK-1 bispecific antibody that promotes superior fracture repair in rodents and bone formation in primates. |
| format |
article |
| author |
Monica Florio Kannan Gunasekaran Marina Stolina Xiaodong Li Ling Liu Barbara Tipton Hossein Salimi-Moosavi Franklin J. Asuncion Chaoyang Li Banghua Sun Hong Lin Tan Li Zhang Chun-Ya Han Ryan Case Amy N. Duguay Mario Grisanti Jennitte Stevens James K. Pretorius Efrain Pacheco Heidi Jones Qing Chen Brian D. Soriano Jie Wen Brenda Heron Frederick W. Jacobsen Emil Brisan William G. Richards Hua Zhu Ke Michael S. Ominsky |
| author_facet |
Monica Florio Kannan Gunasekaran Marina Stolina Xiaodong Li Ling Liu Barbara Tipton Hossein Salimi-Moosavi Franklin J. Asuncion Chaoyang Li Banghua Sun Hong Lin Tan Li Zhang Chun-Ya Han Ryan Case Amy N. Duguay Mario Grisanti Jennitte Stevens James K. Pretorius Efrain Pacheco Heidi Jones Qing Chen Brian D. Soriano Jie Wen Brenda Heron Frederick W. Jacobsen Emil Brisan William G. Richards Hua Zhu Ke Michael S. Ominsky |
| author_sort |
Monica Florio |
| title |
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair |
| title_short |
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair |
| title_full |
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair |
| title_fullStr |
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair |
| title_full_unstemmed |
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair |
| title_sort |
bispecific antibody targeting sclerostin and dkk-1 promotes bone mass accrual and fracture repair |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/5b80b8c1d296447f878d119b9b8140cb |
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