The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire

Abstract Neisseria meningitidis infections are a major issue for global health. The invasive MenC ST-103 clonal complex (CC103) has been the most prevalent in meningococcal outbreaks in Brazil, occurring also in several countries worldwide. Here we have analysed the population structure and accessor...

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Autores principales:	Michel Abanto Marin, Erica Fonseca, Fernando Encinas, Fernanda Freitas, Dhian Almeida Camargo, Roney Santos Coimbra, Ivano de Filippis, Ana Carolina Vicente
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5b81327c57374f1f91ad54369b2d3ab1
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spelling	oai:doaj.org-article:5b81327c57374f1f91ad54369b2d3ab12021-12-02T15:06:25ZThe invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire10.1038/s41598-017-01671-x2045-2322https://doaj.org/article/5b81327c57374f1f91ad54369b2d3ab12017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01671-xhttps://doaj.org/toc/2045-2322Abstract Neisseria meningitidis infections are a major issue for global health. The invasive MenC ST-103 clonal complex (CC103) has been the most prevalent in meningococcal outbreaks in Brazil, occurring also in several countries worldwide. Here we have analysed the population structure and accessory genome of MenC CC103 strains from a global perspective. An in-depth phylogenomic analysis revealed a lineage of N. meningitidis causing meningitis in Brazil and the United Kingdom. This lineage was also characterized as harbouring a particular accessory genome composed of CRISPR/Cas and restriction modification systems. This lineage was also characterized by a genomic island resembling an integrative and conjugative element. This island carried genes potentially associated with virulence and fitness. We propose this accessory gene repertoire could be contributing to the spatial-temporal persistence of the invasive MenC CC103 lineage.Michel Abanto MarinErica FonsecaFernando EncinasFernanda FreitasDhian Almeida CamargoRoney Santos CoimbraIvano de FilippisAna Carolina VicenteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michel Abanto Marin Erica Fonseca Fernando Encinas Fernanda Freitas Dhian Almeida Camargo Roney Santos Coimbra Ivano de Filippis Ana Carolina Vicente The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
description	Abstract Neisseria meningitidis infections are a major issue for global health. The invasive MenC ST-103 clonal complex (CC103) has been the most prevalent in meningococcal outbreaks in Brazil, occurring also in several countries worldwide. Here we have analysed the population structure and accessory genome of MenC CC103 strains from a global perspective. An in-depth phylogenomic analysis revealed a lineage of N. meningitidis causing meningitis in Brazil and the United Kingdom. This lineage was also characterized as harbouring a particular accessory genome composed of CRISPR/Cas and restriction modification systems. This lineage was also characterized by a genomic island resembling an integrative and conjugative element. This island carried genes potentially associated with virulence and fitness. We propose this accessory gene repertoire could be contributing to the spatial-temporal persistence of the invasive MenC CC103 lineage.
format	article
author	Michel Abanto Marin Erica Fonseca Fernando Encinas Fernanda Freitas Dhian Almeida Camargo Roney Santos Coimbra Ivano de Filippis Ana Carolina Vicente
author_facet	Michel Abanto Marin Erica Fonseca Fernando Encinas Fernanda Freitas Dhian Almeida Camargo Roney Santos Coimbra Ivano de Filippis Ana Carolina Vicente
author_sort	Michel Abanto Marin
title	The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
title_short	The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
title_full	The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
title_fullStr	The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
title_full_unstemmed	The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
title_sort	invasive neisseria meningitidis menc cc103 from brazil is characterized by an accessory gene repertoire
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5b81327c57374f1f91ad54369b2d3ab1
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The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire

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