Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation

Saponin-based adjuvants are being explored as vaccine components as they induce high levels of antigen cross-presentation, but it is unknown how. Here the authors show that these adjuvants enhance cross-presentation by driving production of lipid bodies inside CD11b dendritic cells.

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Autores principales:	Martijn H. den Brok, Christian Büll, Melissa Wassink, Annemarie M. de Graaf, Jori A. Wagenaars, Marthe Minderman, Mayank Thakur, Sebastian Amigorena, Eric O. Rijke, Carla C. Schrier, Gosse J. Adema
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b83830e5f2e45ffac906cc79476ab4a
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spelling	oai:doaj.org-article:5b83830e5f2e45ffac906cc79476ab4a2021-12-02T16:50:13ZSaponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation10.1038/ncomms133242041-1723https://doaj.org/article/5b83830e5f2e45ffac906cc79476ab4a2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13324https://doaj.org/toc/2041-1723Saponin-based adjuvants are being explored as vaccine components as they induce high levels of antigen cross-presentation, but it is unknown how. Here the authors show that these adjuvants enhance cross-presentation by driving production of lipid bodies inside CD11b dendritic cells.Martijn H. den BrokChristian BüllMelissa WassinkAnnemarie M. de GraafJori A. WagenaarsMarthe MindermanMayank ThakurSebastian AmigorenaEric O. RijkeCarla C. SchrierGosse J. AdemaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martijn H. den Brok Christian Büll Melissa Wassink Annemarie M. de Graaf Jori A. Wagenaars Marthe Minderman Mayank Thakur Sebastian Amigorena Eric O. Rijke Carla C. Schrier Gosse J. Adema Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
description	Saponin-based adjuvants are being explored as vaccine components as they induce high levels of antigen cross-presentation, but it is unknown how. Here the authors show that these adjuvants enhance cross-presentation by driving production of lipid bodies inside CD11b dendritic cells.
format	article
author	Martijn H. den Brok Christian Büll Melissa Wassink Annemarie M. de Graaf Jori A. Wagenaars Marthe Minderman Mayank Thakur Sebastian Amigorena Eric O. Rijke Carla C. Schrier Gosse J. Adema
author_facet	Martijn H. den Brok Christian Büll Melissa Wassink Annemarie M. de Graaf Jori A. Wagenaars Marthe Minderman Mayank Thakur Sebastian Amigorena Eric O. Rijke Carla C. Schrier Gosse J. Adema
author_sort	Martijn H. den Brok
title	Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
title_short	Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
title_full	Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
title_fullStr	Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
title_full_unstemmed	Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
title_sort	saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5b83830e5f2e45ffac906cc79476ab4a
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Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation

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