Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome

Aim. To evaluate the efficiency of topical negative pressure wound therapy (NPWT) compared with standard therapy for the regeneration of the soft tissues of the lower extremities in patients with diabetic foot syndrome. Materials and Methods. The effects of negative pressure therapy on the clinica...

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Autores principales:	Ekaterina Leonidovna Zaytseva, Ludmila Petrovna Doronina, Roman Vakhtangovich Molchkov, Iya Alexandrovna Voronkova, Valeriy Afanasievich Mitish, Alla Yur'evna Tokmakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2014
Materias:	diabetes mellitus chronic wounds local treatment negative pressure therapy tissue repair immunohistochemical markers histology Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/5b86b61eba84499180e1be21d662d9de
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spelling	oai:doaj.org-article:5b86b61eba84499180e1be21d662d9de2021-11-14T09:00:19ZEffect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome2072-03512072-037810.14341/DM20143113-121https://doaj.org/article/5b86b61eba84499180e1be21d662d9de2014-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6612https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To evaluate the efficiency of topical negative pressure wound therapy (NPWT) compared with standard therapy for the regeneration of the soft tissues of the lower extremities in patients with diabetic foot syndrome. Materials and Methods. The effects of negative pressure therapy on the clinical (size, tissue oxygenation), histological (light microscopy) and immunohistochemical (CD68, MMP-9, TIMP-1) aspects of repair of the soft tissue of the lower extremities in patients with diabetes mellitus were compared with those of standard treatment. Thirty-one patients with diabetic foot ulcers were included in the study from the moment of debridement until the plastic closure of the wound. During the perioperative period, 13 patients received NPWT (-90 to -120 mmHg) and 18 patients received standard therapy. Results. A reduction of the wound area (26.6%?17.2%) and the depth of the defects (40.5%?25.6%) were achieved with negative pressure therapy compared with baseline data. In the control group, the corresponding values were 25.3%?19.4% and 21.8%?21.6%, respectively. The results of transcutaneous oximetry showed a greater increase in the level of local hemodynamics in the study group (pEkaterina Leonidovna ZaytsevaLudmila Petrovna DoroninaRoman Vakhtangovich MolchkovIya Alexandrovna VoronkovaValeriy Afanasievich MitishAlla Yur'evna TokmakovaEndocrinology Research Centrearticlediabetes mellituschronic woundslocal treatmentnegative pressure therapytissue repairimmunohistochemical markershistologyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 3, Pp 113-121 (2014)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus chronic wounds local treatment negative pressure therapy tissue repair immunohistochemical markers histology Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus chronic wounds local treatment negative pressure therapy tissue repair immunohistochemical markers histology Nutritional diseases. Deficiency diseases RC620-627 Ekaterina Leonidovna Zaytseva Ludmila Petrovna Doronina Roman Vakhtangovich Molchkov Iya Alexandrovna Voronkova Valeriy Afanasievich Mitish Alla Yur'evna Tokmakova Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome
description	Aim. To evaluate the efficiency of topical negative pressure wound therapy (NPWT) compared with standard therapy for the regeneration of the soft tissues of the lower extremities in patients with diabetic foot syndrome. Materials and Methods. The effects of negative pressure therapy on the clinical (size, tissue oxygenation), histological (light microscopy) and immunohistochemical (CD68, MMP-9, TIMP-1) aspects of repair of the soft tissue of the lower extremities in patients with diabetes mellitus were compared with those of standard treatment. Thirty-one patients with diabetic foot ulcers were included in the study from the moment of debridement until the plastic closure of the wound. During the perioperative period, 13 patients received NPWT (-90 to -120 mmHg) and 18 patients received standard therapy. Results. A reduction of the wound area (26.6%?17.2%) and the depth of the defects (40.5%?25.6%) were achieved with negative pressure therapy compared with baseline data. In the control group, the corresponding values were 25.3%?19.4% and 21.8%?21.6%, respectively. The results of transcutaneous oximetry showed a greater increase in the level of local hemodynamics in the study group (p
format	article
author	Ekaterina Leonidovna Zaytseva Ludmila Petrovna Doronina Roman Vakhtangovich Molchkov Iya Alexandrovna Voronkova Valeriy Afanasievich Mitish Alla Yur'evna Tokmakova
author_facet	Ekaterina Leonidovna Zaytseva Ludmila Petrovna Doronina Roman Vakhtangovich Molchkov Iya Alexandrovna Voronkova Valeriy Afanasievich Mitish Alla Yur'evna Tokmakova
author_sort	Ekaterina Leonidovna Zaytseva
title	Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome
title_short	Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome
title_full	Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome
title_fullStr	Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome
title_full_unstemmed	Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome
title_sort	effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome
publisher	Endocrinology Research Centre
publishDate	2014
url	https://doaj.org/article/5b86b61eba84499180e1be21d662d9de
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Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome

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