Immunoregulatory potential of pregnancy-specific β1-glycoprotein

The embryo, being half an antigenically “foreign” organism, should elicit a maternal immune response. During evolution, however, the mechanisms ensuring successful development of pregnancy have been formed. In particular, among factors providing immune tolerance during pregnancy are some proteins as...

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Autores principales:	V. P. Timganova, M. S. Bochkova, M. B. Rayev, P. V. Khramtsov, S. A. Zamorina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	pregnancy-specific β 1-glycoprotein immunomodulatory effects immunocompetent cells fetomaternal immune tolerance Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5b885e51e136486ebd4ea066593aa677
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spelling	oai:doaj.org-article:5b885e51e136486ebd4ea066593aa6772021-11-18T08:03:51ZImmunoregulatory potential of pregnancy-specific β1-glycoprotein1563-06252313-741X10.15789/1563-0625-IPO-2170https://doaj.org/article/5b885e51e136486ebd4ea066593aa6772021-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2170https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe embryo, being half an antigenically “foreign” organism, should elicit a maternal immune response. During evolution, however, the mechanisms ensuring successful development of pregnancy have been formed. In particular, among factors providing immune tolerance during pregnancy are some proteins associated with pregnancy. The pregnancy-specific β 1-glycoprotein (PSG, PSG1; SP1; PSβG1) is a dominant fetoplacental protein produced by cyto- and syncytiotrophoblast cells, and it exhibits immunosuppressive properties. Our team of authors possesses a patented method for obtaining native human PSG preparation from blood serum of pregnant women, a mixture of PSG1, PSG3, PSG7, PSG9, and their isoforms and precursors. This review presents an analysis of our results for the period from 2015 to 2020. We studied the immunoregu-latory effects of the obtained PSG preparation at concentrations comparable to those observed in pregnancy (1, 10, 100 \|ag/mL). The study was performed with peripheral blood cells obtained from non-pregnant women. It was found that PSG significantly increased the percentage of adaptive Tregs in vitro, as well as expression of CTLA-4, GITR, and production of IL-10 by these cells. It has been shown that PSG has a stimulating effect upon indoleamine-2,3-dioxygenase (IDO) activity of peripheral blood monocytes. For Th17 cells, we have demonstrated that PSG can suppress differentiation and proliferation of these cells, along with reduced production of critical proinflammatory cytokines (IL-8, IL-10, IL-17, IFNγ, MCP-1, TNF α). As for the memory T cells, PSG suppressed CD25 expression and IL-2 production by them, along with simultaneous decreased expression of Gfi1, hnRNPLL genes, thus preventing the formation of the “mature” CD45R0 isoform. PSG has been shown to inhibit naive T cells’ conversion to the terminally differentiated effector subpopulation of helper T cells. When analyzing PSG effects upon cytokine profile of immunocompetent cells, it was found that the protein predominantly suppresses the Th1 cytokine production by the studied cell types, and regulates the Th2 cytokine production in divergent manner. The results obtained are consistent with general concept of immunosuppression during pregnancy. Thus, PSG could be one of the factors preventing formation and implementation of immune response to placental antigens.V. P. TimganovaM. S. BochkovaM. B. RayevP. V. KhramtsovS. A. ZamorinaSPb RAACIarticlepregnancy-specific β 1-glycoproteinimmunomodulatory effectsimmunocompetent cellsfetomaternal immune toleranceImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 3, Pp 455-468 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	pregnancy-specific β 1-glycoprotein immunomodulatory effects immunocompetent cells fetomaternal immune tolerance Immunologic diseases. Allergy RC581-607
spellingShingle	pregnancy-specific β 1-glycoprotein immunomodulatory effects immunocompetent cells fetomaternal immune tolerance Immunologic diseases. Allergy RC581-607 V. P. Timganova M. S. Bochkova M. B. Rayev P. V. Khramtsov S. A. Zamorina Immunoregulatory potential of pregnancy-specific β1-glycoprotein
description	The embryo, being half an antigenically “foreign” organism, should elicit a maternal immune response. During evolution, however, the mechanisms ensuring successful development of pregnancy have been formed. In particular, among factors providing immune tolerance during pregnancy are some proteins associated with pregnancy. The pregnancy-specific β 1-glycoprotein (PSG, PSG1; SP1; PSβG1) is a dominant fetoplacental protein produced by cyto- and syncytiotrophoblast cells, and it exhibits immunosuppressive properties. Our team of authors possesses a patented method for obtaining native human PSG preparation from blood serum of pregnant women, a mixture of PSG1, PSG3, PSG7, PSG9, and their isoforms and precursors. This review presents an analysis of our results for the period from 2015 to 2020. We studied the immunoregu-latory effects of the obtained PSG preparation at concentrations comparable to those observed in pregnancy (1, 10, 100 \|ag/mL). The study was performed with peripheral blood cells obtained from non-pregnant women. It was found that PSG significantly increased the percentage of adaptive Tregs in vitro, as well as expression of CTLA-4, GITR, and production of IL-10 by these cells. It has been shown that PSG has a stimulating effect upon indoleamine-2,3-dioxygenase (IDO) activity of peripheral blood monocytes. For Th17 cells, we have demonstrated that PSG can suppress differentiation and proliferation of these cells, along with reduced production of critical proinflammatory cytokines (IL-8, IL-10, IL-17, IFNγ, MCP-1, TNF α). As for the memory T cells, PSG suppressed CD25 expression and IL-2 production by them, along with simultaneous decreased expression of Gfi1, hnRNPLL genes, thus preventing the formation of the “mature” CD45R0 isoform. PSG has been shown to inhibit naive T cells’ conversion to the terminally differentiated effector subpopulation of helper T cells. When analyzing PSG effects upon cytokine profile of immunocompetent cells, it was found that the protein predominantly suppresses the Th1 cytokine production by the studied cell types, and regulates the Th2 cytokine production in divergent manner. The results obtained are consistent with general concept of immunosuppression during pregnancy. Thus, PSG could be one of the factors preventing formation and implementation of immune response to placental antigens.
format	article
author	V. P. Timganova M. S. Bochkova M. B. Rayev P. V. Khramtsov S. A. Zamorina
author_facet	V. P. Timganova M. S. Bochkova M. B. Rayev P. V. Khramtsov S. A. Zamorina
author_sort	V. P. Timganova
title	Immunoregulatory potential of pregnancy-specific β1-glycoprotein
title_short	Immunoregulatory potential of pregnancy-specific β1-glycoprotein
title_full	Immunoregulatory potential of pregnancy-specific β1-glycoprotein
title_fullStr	Immunoregulatory potential of pregnancy-specific β1-glycoprotein
title_full_unstemmed	Immunoregulatory potential of pregnancy-specific β1-glycoprotein
title_sort	immunoregulatory potential of pregnancy-specific β1-glycoprotein
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/5b885e51e136486ebd4ea066593aa677
work_keys_str_mv	AT vptimganova immunoregulatorypotentialofpregnancyspecificb1glycoprotein AT msbochkova immunoregulatorypotentialofpregnancyspecificb1glycoprotein AT mbrayev immunoregulatorypotentialofpregnancyspecificb1glycoprotein AT pvkhramtsov immunoregulatorypotentialofpregnancyspecificb1glycoprotein AT sazamorina immunoregulatorypotentialofpregnancyspecificb1glycoprotein
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Immunoregulatory potential of pregnancy-specific β1-glycoprotein

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