Pharmacological insights into autophagy modulation in autoimmune diseases

As a cellular bulk degradation and survival mechanism, autophagy is implicated in diverse biological processes. Genome-wide association studies have revealed the link between autophagy gene polymorphisms and susceptibility of autoimmune diseases including systemic lupus erythematosus (SLE) and infla...

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Autores principales:	Ming-Yue Wu, Er-Jin Wang, Du Feng, Min Li, Richard D. Ye, Jia-Hong Lu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Autophagy Autoimmune disease Systemic lupus erythematosus Inflammatory bowel disease Rheumatoid arthritis Experimental autoimmune encephalomyelitis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5b892209c4cf4d8898b4cebd7fd3acc4
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id	oai:doaj.org-article:5b892209c4cf4d8898b4cebd7fd3acc4
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spelling	oai:doaj.org-article:5b892209c4cf4d8898b4cebd7fd3acc42021-12-02T05:01:21ZPharmacological insights into autophagy modulation in autoimmune diseases2211-383510.1016/j.apsb.2021.03.026https://doaj.org/article/5b892209c4cf4d8898b4cebd7fd3acc42021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211383521000988https://doaj.org/toc/2211-3835As a cellular bulk degradation and survival mechanism, autophagy is implicated in diverse biological processes. Genome-wide association studies have revealed the link between autophagy gene polymorphisms and susceptibility of autoimmune diseases including systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), indicating that autophagy dysregulation may be involved in the development of autoimmune diseases. A series of autophagy modulators have displayed protective effects on autoimmune disease models, highlighting the emerging role of autophagy modulators in treating autoimmune diseases. This review explores the roles of autophagy in the autoimmune diseases, with emphasis on four major autoimmune diseases [SLE, rheumatoid arthritis (RA), IBD, and experimental autoimmune encephalomyelitis (EAE)]. More importantly, the therapeutic potentials of small molecular autophagy modulators (including autophagy inducers and inhibitors) on autoimmune diseases are comprehensively analyzed.Ming-Yue WuEr-Jin WangDu FengMin LiRichard D. YeJia-Hong LuElsevierarticleAutophagyAutoimmune diseaseSystemic lupus erythematosusInflammatory bowel diseaseRheumatoid arthritisExperimental autoimmune encephalomyelitisTherapeutics. PharmacologyRM1-950ENActa Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3364-3378 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Autophagy Autoimmune disease Systemic lupus erythematosus Inflammatory bowel disease Rheumatoid arthritis Experimental autoimmune encephalomyelitis Therapeutics. Pharmacology RM1-950
spellingShingle	Autophagy Autoimmune disease Systemic lupus erythematosus Inflammatory bowel disease Rheumatoid arthritis Experimental autoimmune encephalomyelitis Therapeutics. Pharmacology RM1-950 Ming-Yue Wu Er-Jin Wang Du Feng Min Li Richard D. Ye Jia-Hong Lu Pharmacological insights into autophagy modulation in autoimmune diseases
description	As a cellular bulk degradation and survival mechanism, autophagy is implicated in diverse biological processes. Genome-wide association studies have revealed the link between autophagy gene polymorphisms and susceptibility of autoimmune diseases including systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), indicating that autophagy dysregulation may be involved in the development of autoimmune diseases. A series of autophagy modulators have displayed protective effects on autoimmune disease models, highlighting the emerging role of autophagy modulators in treating autoimmune diseases. This review explores the roles of autophagy in the autoimmune diseases, with emphasis on four major autoimmune diseases [SLE, rheumatoid arthritis (RA), IBD, and experimental autoimmune encephalomyelitis (EAE)]. More importantly, the therapeutic potentials of small molecular autophagy modulators (including autophagy inducers and inhibitors) on autoimmune diseases are comprehensively analyzed.
format	article
author	Ming-Yue Wu Er-Jin Wang Du Feng Min Li Richard D. Ye Jia-Hong Lu
author_facet	Ming-Yue Wu Er-Jin Wang Du Feng Min Li Richard D. Ye Jia-Hong Lu
author_sort	Ming-Yue Wu
title	Pharmacological insights into autophagy modulation in autoimmune diseases
title_short	Pharmacological insights into autophagy modulation in autoimmune diseases
title_full	Pharmacological insights into autophagy modulation in autoimmune diseases
title_fullStr	Pharmacological insights into autophagy modulation in autoimmune diseases
title_full_unstemmed	Pharmacological insights into autophagy modulation in autoimmune diseases
title_sort	pharmacological insights into autophagy modulation in autoimmune diseases
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5b892209c4cf4d8898b4cebd7fd3acc4
work_keys_str_mv	AT mingyuewu pharmacologicalinsightsintoautophagymodulationinautoimmunediseases AT erjinwang pharmacologicalinsightsintoautophagymodulationinautoimmunediseases AT dufeng pharmacologicalinsightsintoautophagymodulationinautoimmunediseases AT minli pharmacologicalinsightsintoautophagymodulationinautoimmunediseases AT richarddye pharmacologicalinsightsintoautophagymodulationinautoimmunediseases AT jiahonglu pharmacologicalinsightsintoautophagymodulationinautoimmunediseases
_version_	1718400829712498688

Pharmacological insights into autophagy modulation in autoimmune diseases

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