Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM

Ryanodine Receptors (RyRs) release Ca2+ from the endoplasmic and sarcoplasmic reticulum. Mutations in RyR are linked to malignant hyperthermia (MH), myopathies, and arrhythmias. Here, a collection of cryoEM structures provides insights into the molecular consequences of MHrelated RyR mutation R615C,...

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Autores principales:	Kellie A. Woll, Omid Haji-Ghassemi, Filip Van Petegem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b8b8e463ac84da9b0bd3809f5a34d32
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spelling	oai:doaj.org-article:5b8b8e463ac84da9b0bd3809f5a34d322021-12-02T10:44:18ZPathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM10.1038/s41467-021-21141-32041-1723https://doaj.org/article/5b8b8e463ac84da9b0bd3809f5a34d322021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21141-3https://doaj.org/toc/2041-1723Ryanodine Receptors (RyRs) release Ca2+ from the endoplasmic and sarcoplasmic reticulum. Mutations in RyR are linked to malignant hyperthermia (MH), myopathies, and arrhythmias. Here, a collection of cryoEM structures provides insights into the molecular consequences of MHrelated RyR mutation R615C, and how apoCaM opens RyR1.Kellie A. WollOmid Haji-GhassemiFilip Van PetegemNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kellie A. Woll Omid Haji-Ghassemi Filip Van Petegem Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM
description	Ryanodine Receptors (RyRs) release Ca2+ from the endoplasmic and sarcoplasmic reticulum. Mutations in RyR are linked to malignant hyperthermia (MH), myopathies, and arrhythmias. Here, a collection of cryoEM structures provides insights into the molecular consequences of MHrelated RyR mutation R615C, and how apoCaM opens RyR1.
format	article
author	Kellie A. Woll Omid Haji-Ghassemi Filip Van Petegem
author_facet	Kellie A. Woll Omid Haji-Ghassemi Filip Van Petegem
author_sort	Kellie A. Woll
title	Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM
title_short	Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM
title_full	Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM
title_fullStr	Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM
title_full_unstemmed	Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM
title_sort	pathological conformations of disease mutant ryanodine receptors revealed by cryo-em
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b8b8e463ac84da9b0bd3809f5a34d32
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Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM

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