Cell-to-Cell Interactions Mediating Functional Recovery after Stroke

Ischemic damage in brain tissue triggers a cascade of molecular and structural plastic changes, thus influencing a wide range of cell-to-cell interactions. Understanding and manipulating this scenario of intercellular connections is the Holy Grail for post-stroke neurorehabilitation. Here, we discus...

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Autores principales:	Claudia Alia, Daniele Cangi, Verediana Massa, Marco Salluzzo, Livia Vignozzi, Matteo Caleo, Cristina Spalletti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stroke astrocytes oligodendrocytes microglia interneurons Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5b8e6cfc27b743c3bec1557c51128a19
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spelling	oai:doaj.org-article:5b8e6cfc27b743c3bec1557c51128a192021-11-25T17:10:50ZCell-to-Cell Interactions Mediating Functional Recovery after Stroke10.3390/cells101130502073-4409https://doaj.org/article/5b8e6cfc27b743c3bec1557c51128a192021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3050https://doaj.org/toc/2073-4409Ischemic damage in brain tissue triggers a cascade of molecular and structural plastic changes, thus influencing a wide range of cell-to-cell interactions. Understanding and manipulating this scenario of intercellular connections is the Holy Grail for post-stroke neurorehabilitation. Here, we discuss the main findings in the literature related to post-stroke alterations in cell-to-cell interactions, which may be either detrimental or supportive for functional recovery. We consider both neural and non-neural cells, starting from astrocytes and reactive astrogliosis and moving to the roles of the oligodendrocytes in the support of vulnerable neurons and sprouting inhibition. We discuss the controversial role of microglia in neural inflammation after injury and we conclude with the description of post-stroke alterations in pyramidal and GABAergic cells interactions. For all of these sections, we review not only the spontaneous evolution in cellular interactions after ischemic injury, but also the experimental strategies which have targeted these interactions and that are inspiring novel therapeutic strategies for clinical application.Claudia AliaDaniele CangiVerediana MassaMarco SalluzzoLivia VignozziMatteo CaleoCristina SpallettiMDPI AGarticlestrokeastrocytesoligodendrocytesmicrogliainterneuronsBiology (General)QH301-705.5ENCells, Vol 10, Iss 3050, p 3050 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke astrocytes oligodendrocytes microglia interneurons Biology (General) QH301-705.5
spellingShingle	stroke astrocytes oligodendrocytes microglia interneurons Biology (General) QH301-705.5 Claudia Alia Daniele Cangi Verediana Massa Marco Salluzzo Livia Vignozzi Matteo Caleo Cristina Spalletti Cell-to-Cell Interactions Mediating Functional Recovery after Stroke
description	Ischemic damage in brain tissue triggers a cascade of molecular and structural plastic changes, thus influencing a wide range of cell-to-cell interactions. Understanding and manipulating this scenario of intercellular connections is the Holy Grail for post-stroke neurorehabilitation. Here, we discuss the main findings in the literature related to post-stroke alterations in cell-to-cell interactions, which may be either detrimental or supportive for functional recovery. We consider both neural and non-neural cells, starting from astrocytes and reactive astrogliosis and moving to the roles of the oligodendrocytes in the support of vulnerable neurons and sprouting inhibition. We discuss the controversial role of microglia in neural inflammation after injury and we conclude with the description of post-stroke alterations in pyramidal and GABAergic cells interactions. For all of these sections, we review not only the spontaneous evolution in cellular interactions after ischemic injury, but also the experimental strategies which have targeted these interactions and that are inspiring novel therapeutic strategies for clinical application.
format	article
author	Claudia Alia Daniele Cangi Verediana Massa Marco Salluzzo Livia Vignozzi Matteo Caleo Cristina Spalletti
author_facet	Claudia Alia Daniele Cangi Verediana Massa Marco Salluzzo Livia Vignozzi Matteo Caleo Cristina Spalletti
author_sort	Claudia Alia
title	Cell-to-Cell Interactions Mediating Functional Recovery after Stroke
title_short	Cell-to-Cell Interactions Mediating Functional Recovery after Stroke
title_full	Cell-to-Cell Interactions Mediating Functional Recovery after Stroke
title_fullStr	Cell-to-Cell Interactions Mediating Functional Recovery after Stroke
title_full_unstemmed	Cell-to-Cell Interactions Mediating Functional Recovery after Stroke
title_sort	cell-to-cell interactions mediating functional recovery after stroke
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5b8e6cfc27b743c3bec1557c51128a19
work_keys_str_mv	AT claudiaalia celltocellinteractionsmediatingfunctionalrecoveryafterstroke AT danielecangi celltocellinteractionsmediatingfunctionalrecoveryafterstroke AT veredianamassa celltocellinteractionsmediatingfunctionalrecoveryafterstroke AT marcosalluzzo celltocellinteractionsmediatingfunctionalrecoveryafterstroke AT liviavignozzi celltocellinteractionsmediatingfunctionalrecoveryafterstroke AT matteocaleo celltocellinteractionsmediatingfunctionalrecoveryafterstroke AT cristinaspalletti celltocellinteractionsmediatingfunctionalrecoveryafterstroke
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Cell-to-Cell Interactions Mediating Functional Recovery after Stroke

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