Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage

Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage

Development of broadly neutralizing antibodies (bnAb) against HIV-1 in infected adults is a multi-step process unachievable by current vaccine approaches. Here the authors reconstruct the ontogeny of an infant bnAb, which develops in fewer steps, and identify its unique features that may shorten the...

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Autores principales: Cassandra A. Simonich, Laura Doepker, Duncan Ralph, James A. Williams, Amrit Dhar, Zak Yaffe, Lauren Gentles, Christopher T. Small, Brian Oliver, Vladimir Vigdorovich, Vidya Mangala Prasad, Ruth Nduati, D. Noah Sather, Kelly K. Lee, Frederick A. Matsen IV, Julie Overbaugh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/5b8e79bde5ec414da4937e1e8049ac81
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Sumario:Development of broadly neutralizing antibodies (bnAb) against HIV-1 in infected adults is a multi-step process unachievable by current vaccine approaches. Here the authors reconstruct the ontogeny of an infant bnAb, which develops in fewer steps, and identify its unique features that may shorten the path to HIV vaccines.

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