Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage

Development of broadly neutralizing antibodies (bnAb) against HIV-1 in infected adults is a multi-step process unachievable by current vaccine approaches. Here the authors reconstruct the ontogeny of an infant bnAb, which develops in fewer steps, and identify its unique features that may shorten the...

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Autores principales:	Cassandra A. Simonich, Laura Doepker, Duncan Ralph, James A. Williams, Amrit Dhar, Zak Yaffe, Lauren Gentles, Christopher T. Small, Brian Oliver, Vladimir Vigdorovich, Vidya Mangala Prasad, Ruth Nduati, D. Noah Sather, Kelly K. Lee, Frederick A. Matsen IV, Julie Overbaugh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b8e79bde5ec414da4937e1e8049ac81
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spelling	oai:doaj.org-article:5b8e79bde5ec414da4937e1e8049ac812021-12-02T17:01:48ZKappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage10.1038/s41467-019-09481-72041-1723https://doaj.org/article/5b8e79bde5ec414da4937e1e8049ac812019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09481-7https://doaj.org/toc/2041-1723Development of broadly neutralizing antibodies (bnAb) against HIV-1 in infected adults is a multi-step process unachievable by current vaccine approaches. Here the authors reconstruct the ontogeny of an infant bnAb, which develops in fewer steps, and identify its unique features that may shorten the path to HIV vaccines.Cassandra A. SimonichLaura DoepkerDuncan RalphJames A. WilliamsAmrit DharZak YaffeLauren GentlesChristopher T. SmallBrian OliverVladimir VigdorovichVidya Mangala PrasadRuth NduatiD. Noah SatherKelly K. LeeFrederick A. Matsen IVJulie OverbaughNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cassandra A. Simonich Laura Doepker Duncan Ralph James A. Williams Amrit Dhar Zak Yaffe Lauren Gentles Christopher T. Small Brian Oliver Vladimir Vigdorovich Vidya Mangala Prasad Ruth Nduati D. Noah Sather Kelly K. Lee Frederick A. Matsen IV Julie Overbaugh Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage
description	Development of broadly neutralizing antibodies (bnAb) against HIV-1 in infected adults is a multi-step process unachievable by current vaccine approaches. Here the authors reconstruct the ontogeny of an infant bnAb, which develops in fewer steps, and identify its unique features that may shorten the path to HIV vaccines.
format	article
author	Cassandra A. Simonich Laura Doepker Duncan Ralph James A. Williams Amrit Dhar Zak Yaffe Lauren Gentles Christopher T. Small Brian Oliver Vladimir Vigdorovich Vidya Mangala Prasad Ruth Nduati D. Noah Sather Kelly K. Lee Frederick A. Matsen IV Julie Overbaugh
author_facet	Cassandra A. Simonich Laura Doepker Duncan Ralph James A. Williams Amrit Dhar Zak Yaffe Lauren Gentles Christopher T. Small Brian Oliver Vladimir Vigdorovich Vidya Mangala Prasad Ruth Nduati D. Noah Sather Kelly K. Lee Frederick A. Matsen IV Julie Overbaugh
author_sort	Cassandra A. Simonich
title	Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage
title_short	Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage
title_full	Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage
title_fullStr	Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage
title_full_unstemmed	Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage
title_sort	kappa chain maturation helps drive rapid development of an infant hiv-1 broadly neutralizing antibody lineage
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5b8e79bde5ec414da4937e1e8049ac81
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Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage

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