Histogram-derived modified thresholds for coronary artery calcium scoring with lower tube voltage

Abstract We aimed to determine the proper modified thresholds for detecting and weighting CAC scores at 100 kV through histogram matching in comparison with 120 kV as a standard reference. From the training set (680 participants), modified thresholds at 100 kV were obtained through histogram matchin...

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Autores principales:	Sungwon Kim, Chan Joo Lee, Kyunghwa Han, Kye Ho Lee, Hye-Jeong Lee, Sungha Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5b92067d9ea24fef9899975b4164cb01
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spelling	oai:doaj.org-article:5b92067d9ea24fef9899975b4164cb012021-12-02T16:38:49ZHistogram-derived modified thresholds for coronary artery calcium scoring with lower tube voltage10.1038/s41598-021-96695-92045-2322https://doaj.org/article/5b92067d9ea24fef9899975b4164cb012021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96695-9https://doaj.org/toc/2045-2322Abstract We aimed to determine the proper modified thresholds for detecting and weighting CAC scores at 100 kV through histogram matching in comparison with 120 kV as a standard reference. From the training set (680 participants), modified thresholds at 100 kV were obtained through histogram matching of calcium pixels to 120 kV. From the validation set (213 participants), a standard CAC score at 120 kV, and modified CAC score at 100 kV using modified thresholds were compare through the paired t test and the Bland–Altman plot. Agreement for risk categories (no, minimal, mild, moderate, and severe) was evaluated using kappa statistics. Radiation doses were also compared. For the validation set, there was no significant difference between standard (median, 18.7; IQR, 0.0–207.0) and modified (median, 17.3; IQR, 0.0–220.9) CAC scores (P = 0.689). A small bias was achieved (0.74) with 95% limits of agreement from − 52.35 to 53.83. Agreements for risk categories were excellent (κ = 0.994). The mean dose-length-product of 100-kV scanning (30.1 ± 0.8 mGy * cm) was significantly decreased compared to 120-kV scanning (42.9 ± 0.6 mGy * cm) (P < 0.001). Histogram-derived modified thresholds at 100 kV can enable accurate CAC scoring while reducing radiation exposure.Sungwon KimChan Joo LeeKyunghwa HanKye Ho LeeHye-Jeong LeeSungha ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sungwon Kim Chan Joo Lee Kyunghwa Han Kye Ho Lee Hye-Jeong Lee Sungha Park Histogram-derived modified thresholds for coronary artery calcium scoring with lower tube voltage
description	Abstract We aimed to determine the proper modified thresholds for detecting and weighting CAC scores at 100 kV through histogram matching in comparison with 120 kV as a standard reference. From the training set (680 participants), modified thresholds at 100 kV were obtained through histogram matching of calcium pixels to 120 kV. From the validation set (213 participants), a standard CAC score at 120 kV, and modified CAC score at 100 kV using modified thresholds were compare through the paired t test and the Bland–Altman plot. Agreement for risk categories (no, minimal, mild, moderate, and severe) was evaluated using kappa statistics. Radiation doses were also compared. For the validation set, there was no significant difference between standard (median, 18.7; IQR, 0.0–207.0) and modified (median, 17.3; IQR, 0.0–220.9) CAC scores (P = 0.689). A small bias was achieved (0.74) with 95% limits of agreement from − 52.35 to 53.83. Agreements for risk categories were excellent (κ = 0.994). The mean dose-length-product of 100-kV scanning (30.1 ± 0.8 mGy * cm) was significantly decreased compared to 120-kV scanning (42.9 ± 0.6 mGy * cm) (P < 0.001). Histogram-derived modified thresholds at 100 kV can enable accurate CAC scoring while reducing radiation exposure.
format	article
author	Sungwon Kim Chan Joo Lee Kyunghwa Han Kye Ho Lee Hye-Jeong Lee Sungha Park
author_facet	Sungwon Kim Chan Joo Lee Kyunghwa Han Kye Ho Lee Hye-Jeong Lee Sungha Park
author_sort	Sungwon Kim
title	Histogram-derived modified thresholds for coronary artery calcium scoring with lower tube voltage
title_short	Histogram-derived modified thresholds for coronary artery calcium scoring with lower tube voltage
title_full	Histogram-derived modified thresholds for coronary artery calcium scoring with lower tube voltage
title_fullStr	Histogram-derived modified thresholds for coronary artery calcium scoring with lower tube voltage
title_full_unstemmed	Histogram-derived modified thresholds for coronary artery calcium scoring with lower tube voltage
title_sort	histogram-derived modified thresholds for coronary artery calcium scoring with lower tube voltage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b92067d9ea24fef9899975b4164cb01
work_keys_str_mv	AT sungwonkim histogramderivedmodifiedthresholdsforcoronaryarterycalciumscoringwithlowertubevoltage AT chanjoolee histogramderivedmodifiedthresholdsforcoronaryarterycalciumscoringwithlowertubevoltage AT kyunghwahan histogramderivedmodifiedthresholdsforcoronaryarterycalciumscoringwithlowertubevoltage AT kyeholee histogramderivedmodifiedthresholdsforcoronaryarterycalciumscoringwithlowertubevoltage AT hyejeonglee histogramderivedmodifiedthresholdsforcoronaryarterycalciumscoringwithlowertubevoltage AT sunghapark histogramderivedmodifiedthresholdsforcoronaryarterycalciumscoringwithlowertubevoltage
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Histogram-derived modified thresholds for coronary artery calcium scoring with lower tube voltage

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