The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis

Genomic amplification of chromosome 3q often encodes proteins that contribute to cancer development. Here the authors identify a non-coding product of the 3q region, the lncRNA PLANE that promotes tumorigenesis through the deregulation of transcriptional corepressor NCOR2 pre-mRNA splicing.

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Autores principales:	Liu Teng, Yu Chen Feng, Su Tang Guo, Pei Lin Wang, Teng Fei Qi, Yi Meng Yue, Shi Xing Wang, Sheng Nan Zhang, Cai Xia Tang, Ting La, Yuan Yuan Zhang, Xiao Hong Zhao, Jin Nan Gao, Li Yuan Wei, Didi Zhang, Jenny Y. Wang, Yujie Shi, Xiao Ying Liu, Jin Ming Li, Huixia Cao, Tao Liu, Rick F. Thorne, Lei Jin, Feng-Min Shao, Xu Dong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b9cdaaeb58b43eabf91f4a962656e8e
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spelling	oai:doaj.org-article:5b9cdaaeb58b43eabf91f4a962656e8e2021-12-02T17:39:56ZThe pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis10.1038/s41467-021-24099-42041-1723https://doaj.org/article/5b9cdaaeb58b43eabf91f4a962656e8e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24099-4https://doaj.org/toc/2041-1723Genomic amplification of chromosome 3q often encodes proteins that contribute to cancer development. Here the authors identify a non-coding product of the 3q region, the lncRNA PLANE that promotes tumorigenesis through the deregulation of transcriptional corepressor NCOR2 pre-mRNA splicing.Liu TengYu Chen FengSu Tang GuoPei Lin WangTeng Fei QiYi Meng YueShi Xing WangSheng Nan ZhangCai Xia TangTing LaYuan Yuan ZhangXiao Hong ZhaoJin Nan GaoLi Yuan WeiDidi ZhangJenny Y. WangYujie ShiXiao Ying LiuJin Ming LiHuixia CaoTao LiuRick F. ThorneLei JinFeng-Min ShaoXu Dong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liu Teng Yu Chen Feng Su Tang Guo Pei Lin Wang Teng Fei Qi Yi Meng Yue Shi Xing Wang Sheng Nan Zhang Cai Xia Tang Ting La Yuan Yuan Zhang Xiao Hong Zhao Jin Nan Gao Li Yuan Wei Didi Zhang Jenny Y. Wang Yujie Shi Xiao Ying Liu Jin Ming Li Huixia Cao Tao Liu Rick F. Thorne Lei Jin Feng-Min Shao Xu Dong Zhang The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis
description	Genomic amplification of chromosome 3q often encodes proteins that contribute to cancer development. Here the authors identify a non-coding product of the 3q region, the lncRNA PLANE that promotes tumorigenesis through the deregulation of transcriptional corepressor NCOR2 pre-mRNA splicing.
format	article
author	Liu Teng Yu Chen Feng Su Tang Guo Pei Lin Wang Teng Fei Qi Yi Meng Yue Shi Xing Wang Sheng Nan Zhang Cai Xia Tang Ting La Yuan Yuan Zhang Xiao Hong Zhao Jin Nan Gao Li Yuan Wei Didi Zhang Jenny Y. Wang Yujie Shi Xiao Ying Liu Jin Ming Li Huixia Cao Tao Liu Rick F. Thorne Lei Jin Feng-Min Shao Xu Dong Zhang
author_facet	Liu Teng Yu Chen Feng Su Tang Guo Pei Lin Wang Teng Fei Qi Yi Meng Yue Shi Xing Wang Sheng Nan Zhang Cai Xia Tang Ting La Yuan Yuan Zhang Xiao Hong Zhao Jin Nan Gao Li Yuan Wei Didi Zhang Jenny Y. Wang Yujie Shi Xiao Ying Liu Jin Ming Li Huixia Cao Tao Liu Rick F. Thorne Lei Jin Feng-Min Shao Xu Dong Zhang
author_sort	Liu Teng
title	The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis
title_short	The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis
title_full	The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis
title_fullStr	The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis
title_full_unstemmed	The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis
title_sort	pan-cancer lncrna plane regulates an alternative splicing program to promote cancer pathogenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b9cdaaeb58b43eabf91f4a962656e8e
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The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis

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