Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses

The gut microbiome is involved in the host’s metabolism, development, and immunity, which translates to measurable impacts on disease risk and overall health. Emerging evidence supports pulses, i.e., grain legumes, as underutilized nutrient-dense, culinarily versatile, and sustainable staple foods t...

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Autores principales:	Tymofiy Lutsiv, Tiffany L. Weir, John N. McGinley, Elizabeth S. Neil, Yuren Wei, Henry J. Thompson
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lentil chickpea dry pea common bean pulses high-fat diet Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/5b9d0b7456c74fda80b98463f5ded9bd
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spelling	oai:doaj.org-article:5b9d0b7456c74fda80b98463f5ded9bd2021-11-25T18:35:52ZCompositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses10.3390/nu131139922072-6643https://doaj.org/article/5b9d0b7456c74fda80b98463f5ded9bd2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3992https://doaj.org/toc/2072-6643The gut microbiome is involved in the host’s metabolism, development, and immunity, which translates to measurable impacts on disease risk and overall health. Emerging evidence supports pulses, i.e., grain legumes, as underutilized nutrient-dense, culinarily versatile, and sustainable staple foods that promote health benefits through modulating the gut microbiota. Herein, the effects of pulse consumption on microbial composition in the cecal content of mice were assessed. Male mice were fed an obesogenic diet formulation with or without 35% of the protein component comprised by each of four commonly consumed pulses—lentil (<i>Lens culinaris</i> L.), chickpea (<i>Cicer arietinum</i> L.), common bean (<i>Phaseolus vulgaris</i> L.), or dry pea (<i>Pisum sativum</i> L.). Mice consuming pulses had distinct microbial communities from animals on the pulse-free diet, as evidenced by β-diversity ordinations. At the phylum level, animals consuming pulses showed an increase in Bacteroidetes and decreases in Proteobacteria and Firmicutes. Furthermore, α-diversity was significantly higher in pulse-fed animals. An ecosystem of the common bacteria that were enhanced, suppressed, or unaffected by most of the pulses was identified. These compositional changes are accompanied by shifts in predicted metagenome functions and are concurrent with previously reported anti-obesogenic physiologic outcomes, suggestive of microbiota-associated benefits of pulse consumption.Tymofiy LutsivTiffany L. WeirJohn N. McGinleyElizabeth S. NeilYuren WeiHenry J. ThompsonMDPI AGarticlelentilchickpeadry peacommon beanpulseshigh-fat dietNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3992, p 3992 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lentil chickpea dry pea common bean pulses high-fat diet Nutrition. Foods and food supply TX341-641
spellingShingle	lentil chickpea dry pea common bean pulses high-fat diet Nutrition. Foods and food supply TX341-641 Tymofiy Lutsiv Tiffany L. Weir John N. McGinley Elizabeth S. Neil Yuren Wei Henry J. Thompson Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
description	The gut microbiome is involved in the host’s metabolism, development, and immunity, which translates to measurable impacts on disease risk and overall health. Emerging evidence supports pulses, i.e., grain legumes, as underutilized nutrient-dense, culinarily versatile, and sustainable staple foods that promote health benefits through modulating the gut microbiota. Herein, the effects of pulse consumption on microbial composition in the cecal content of mice were assessed. Male mice were fed an obesogenic diet formulation with or without 35% of the protein component comprised by each of four commonly consumed pulses—lentil (<i>Lens culinaris</i> L.), chickpea (<i>Cicer arietinum</i> L.), common bean (<i>Phaseolus vulgaris</i> L.), or dry pea (<i>Pisum sativum</i> L.). Mice consuming pulses had distinct microbial communities from animals on the pulse-free diet, as evidenced by β-diversity ordinations. At the phylum level, animals consuming pulses showed an increase in Bacteroidetes and decreases in Proteobacteria and Firmicutes. Furthermore, α-diversity was significantly higher in pulse-fed animals. An ecosystem of the common bacteria that were enhanced, suppressed, or unaffected by most of the pulses was identified. These compositional changes are accompanied by shifts in predicted metagenome functions and are concurrent with previously reported anti-obesogenic physiologic outcomes, suggestive of microbiota-associated benefits of pulse consumption.
format	article
author	Tymofiy Lutsiv Tiffany L. Weir John N. McGinley Elizabeth S. Neil Yuren Wei Henry J. Thompson
author_facet	Tymofiy Lutsiv Tiffany L. Weir John N. McGinley Elizabeth S. Neil Yuren Wei Henry J. Thompson
author_sort	Tymofiy Lutsiv
title	Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
title_short	Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
title_full	Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
title_fullStr	Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
title_full_unstemmed	Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses
title_sort	compositional changes of the high-fat diet-induced gut microbiota upon consumption of common pulses
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5b9d0b7456c74fda80b98463f5ded9bd
work_keys_str_mv	AT tymofiylutsiv compositionalchangesofthehighfatdietinducedgutmicrobiotauponconsumptionofcommonpulses AT tiffanylweir compositionalchangesofthehighfatdietinducedgutmicrobiotauponconsumptionofcommonpulses AT johnnmcginley compositionalchangesofthehighfatdietinducedgutmicrobiotauponconsumptionofcommonpulses AT elizabethsneil compositionalchangesofthehighfatdietinducedgutmicrobiotauponconsumptionofcommonpulses AT yurenwei compositionalchangesofthehighfatdietinducedgutmicrobiotauponconsumptionofcommonpulses AT henryjthompson compositionalchangesofthehighfatdietinducedgutmicrobiotauponconsumptionofcommonpulses
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Compositional Changes of the High-Fat Diet-Induced Gut Microbiota upon Consumption of Common Pulses

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