Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies

The nature of the linker is known to affect the efficacy of antibody–drug conjugate (ADC). Here the authors show cetuximab-guided Avidin-Nucleic-Acid-Nanoassemblies to be superior to cetuximab-doxorubicin conjugate, and show its efficacy in KRAS mutant breast cancer, allowing for therapeutic expansi...

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Autores principales:	Francesco Roncato, Fatlum Rruga, Elena Porcù, Elisabetta Casarin, Roberto Ronca, Federica Maccarinelli, Nicola Realdon, Giuseppe Basso, Ronen Alon, Giampietro Viola, Margherita Morpurgo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b9f1af1b8e049f592c27421c329d673
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spelling	oai:doaj.org-article:5b9f1af1b8e049f592c27421c329d6732021-12-02T14:39:44ZImprovement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies10.1038/s41467-018-06602-62041-1723https://doaj.org/article/5b9f1af1b8e049f592c27421c329d6732018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06602-6https://doaj.org/toc/2041-1723The nature of the linker is known to affect the efficacy of antibody–drug conjugate (ADC). Here the authors show cetuximab-guided Avidin-Nucleic-Acid-Nanoassemblies to be superior to cetuximab-doxorubicin conjugate, and show its efficacy in KRAS mutant breast cancer, allowing for therapeutic expansion of anti-EGFR therapy.Francesco RoncatoFatlum RrugaElena PorcùElisabetta CasarinRoberto RoncaFederica MaccarinelliNicola RealdonGiuseppe BassoRonen AlonGiampietro ViolaMargherita MorpurgoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francesco Roncato Fatlum Rruga Elena Porcù Elisabetta Casarin Roberto Ronca Federica Maccarinelli Nicola Realdon Giuseppe Basso Ronen Alon Giampietro Viola Margherita Morpurgo Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies
description	The nature of the linker is known to affect the efficacy of antibody–drug conjugate (ADC). Here the authors show cetuximab-guided Avidin-Nucleic-Acid-Nanoassemblies to be superior to cetuximab-doxorubicin conjugate, and show its efficacy in KRAS mutant breast cancer, allowing for therapeutic expansion of anti-EGFR therapy.
format	article
author	Francesco Roncato Fatlum Rruga Elena Porcù Elisabetta Casarin Roberto Ronca Federica Maccarinelli Nicola Realdon Giuseppe Basso Ronen Alon Giampietro Viola Margherita Morpurgo
author_facet	Francesco Roncato Fatlum Rruga Elena Porcù Elisabetta Casarin Roberto Ronca Federica Maccarinelli Nicola Realdon Giuseppe Basso Ronen Alon Giampietro Viola Margherita Morpurgo
author_sort	Francesco Roncato
title	Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies
title_short	Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies
title_full	Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies
title_fullStr	Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies
title_full_unstemmed	Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies
title_sort	improvement and extension of anti-egfr targeting in breast cancer therapy by integration with the avidin-nucleic-acid-nano-assemblies
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5b9f1af1b8e049f592c27421c329d673
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Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies

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