A Case Report of Severe Rhabdomyolysis after Lovastatin and Diltiazem Consumption

BACKGROUND AND OBJECTIVE: Muscular involvement presenting as myalgia, myopathy and rhabdomyolysis are the most important side effects of statins. Frequently statins and other antiangina and antihypertensive agent are used as combination in order to preventing and management of atherosclerosis and ca...

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Autores principales:	M Baradaran, A Ahmadi Ahangar
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2010
Materias:	atherosclerosis rhabdomyolysis statin hyperkalemia bradyarrhythmai diltiazem Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5ba20de6410b4c89bb72b029837a1a56
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spelling	oai:doaj.org-article:5ba20de6410b4c89bb72b029837a1a562021-11-10T09:00:37ZA Case Report of Severe Rhabdomyolysis after Lovastatin and Diltiazem Consumption1561-41072251-7170https://doaj.org/article/5ba20de6410b4c89bb72b029837a1a562010-10-01T00:00:00Zhttp://jbums.org/article-1-3673-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Muscular involvement presenting as myalgia, myopathy and rhabdomyolysis are the most important side effects of statins. Frequently statins and other antiangina and antihypertensive agent are used as combination in order to preventing and management of atherosclerosis and cardiovascular and cerobrovascular disorders. Here we present a case of rhabdomyolysis after lovastatin and diltiazem consumption. CASE: An 80 year old man with decreased level of consciousness presented to emergency ward of Shahid Yahyanejad hospital of Babol, Iran. Past medical history revealed diltiazem and lovastatin consumption (40mg/daily) from three days before. Diagnosis of rhabdomyolysis was documented according to history, physical exam and laboratory test regarding hyperkalemia and bradyarrhythmia leading to cardiovascular collapse. During successful resuscitation arrhythmia and hemodynamic failure and hyperkalemia was corrected and patient was discharged from hospital without any morbidity after convalescence. CONCLUSION: The results of this study showed that combination of statins and diltiazem can potentially lead to serious side effects that can be prevented by accenting on pharmacology consideration in prescribing statins and avoiding conjoins these agents with diltazem especially in old age patient.M BaradaranA Ahmadi AhangarBabol University of Medical SciencesarticleatherosclerosisrhabdomyolysisstatinhyperkalemiabradyarrhythmaidiltiazemMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 12, Iss 4, Pp 85-89 (2010)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	atherosclerosis rhabdomyolysis statin hyperkalemia bradyarrhythmai diltiazem Medicine R Medicine (General) R5-920
spellingShingle	atherosclerosis rhabdomyolysis statin hyperkalemia bradyarrhythmai diltiazem Medicine R Medicine (General) R5-920 M Baradaran A Ahmadi Ahangar A Case Report of Severe Rhabdomyolysis after Lovastatin and Diltiazem Consumption
description	BACKGROUND AND OBJECTIVE: Muscular involvement presenting as myalgia, myopathy and rhabdomyolysis are the most important side effects of statins. Frequently statins and other antiangina and antihypertensive agent are used as combination in order to preventing and management of atherosclerosis and cardiovascular and cerobrovascular disorders. Here we present a case of rhabdomyolysis after lovastatin and diltiazem consumption. CASE: An 80 year old man with decreased level of consciousness presented to emergency ward of Shahid Yahyanejad hospital of Babol, Iran. Past medical history revealed diltiazem and lovastatin consumption (40mg/daily) from three days before. Diagnosis of rhabdomyolysis was documented according to history, physical exam and laboratory test regarding hyperkalemia and bradyarrhythmia leading to cardiovascular collapse. During successful resuscitation arrhythmia and hemodynamic failure and hyperkalemia was corrected and patient was discharged from hospital without any morbidity after convalescence. CONCLUSION: The results of this study showed that combination of statins and diltiazem can potentially lead to serious side effects that can be prevented by accenting on pharmacology consideration in prescribing statins and avoiding conjoins these agents with diltazem especially in old age patient.
format	article
author	M Baradaran A Ahmadi Ahangar
author_facet	M Baradaran A Ahmadi Ahangar
author_sort	M Baradaran
title	A Case Report of Severe Rhabdomyolysis after Lovastatin and Diltiazem Consumption
title_short	A Case Report of Severe Rhabdomyolysis after Lovastatin and Diltiazem Consumption
title_full	A Case Report of Severe Rhabdomyolysis after Lovastatin and Diltiazem Consumption
title_fullStr	A Case Report of Severe Rhabdomyolysis after Lovastatin and Diltiazem Consumption
title_full_unstemmed	A Case Report of Severe Rhabdomyolysis after Lovastatin and Diltiazem Consumption
title_sort	case report of severe rhabdomyolysis after lovastatin and diltiazem consumption
publisher	Babol University of Medical Sciences
publishDate	2010
url	https://doaj.org/article/5ba20de6410b4c89bb72b029837a1a56
work_keys_str_mv	AT mbaradaran acasereportofsevererhabdomyolysisafterlovastatinanddiltiazemconsumption AT aahmadiahangar acasereportofsevererhabdomyolysisafterlovastatinanddiltiazemconsumption AT mbaradaran casereportofsevererhabdomyolysisafterlovastatinanddiltiazemconsumption AT aahmadiahangar casereportofsevererhabdomyolysisafterlovastatinanddiltiazemconsumption
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A Case Report of Severe Rhabdomyolysis after Lovastatin and Diltiazem Consumption

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