NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

Nerve/glial antigen 2 (NG2) glia can sense synaptic inputs from neurons. Here, the authors show NG2 glia form functional GABAergic synapses by regulating inhibitory synaptic transmission onto adjacent hippocampal interneurons, and activation of NG2 glia induces anxiety-like behaviour in a mouse mode...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Xiao Zhang, Yao Liu, Xiaoqi Hong, Xia Li, Charles K. Meshul, Cynthia Moore, Yabing Yang, Yanfei Han, Wei-Guang Li, Xin Qi, Huifang Lou, Shumin Duan, Tian-Le Xu, Xiaoping Tong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/5ba3773ac7ef4f6cb15b4d88942f3545
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Nerve/glial antigen 2 (NG2) glia can sense synaptic inputs from neurons. Here, the authors show NG2 glia form functional GABAergic synapses by regulating inhibitory synaptic transmission onto adjacent hippocampal interneurons, and activation of NG2 glia induces anxiety-like behaviour in a mouse model of chronic social defeat stress.

Ejemplares similares