NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

Nerve/glial antigen 2 (NG2) glia can sense synaptic inputs from neurons. Here, the authors show NG2 glia form functional GABAergic synapses by regulating inhibitory synaptic transmission onto adjacent hippocampal interneurons, and activation of NG2 glia induces anxiety-like behaviour in a mouse mode...

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Autores principales:	Xiao Zhang, Yao Liu, Xiaoqi Hong, Xia Li, Charles K. Meshul, Cynthia Moore, Yabing Yang, Yanfei Han, Wei-Guang Li, Xin Qi, Huifang Lou, Shumin Duan, Tian-Le Xu, Xiaoping Tong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ba3773ac7ef4f6cb15b4d88942f3545
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spelling	oai:doaj.org-article:5ba3773ac7ef4f6cb15b4d88942f35452021-12-02T17:18:12ZNG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety10.1038/s41467-021-25956-y2041-1723https://doaj.org/article/5ba3773ac7ef4f6cb15b4d88942f35452021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25956-yhttps://doaj.org/toc/2041-1723Nerve/glial antigen 2 (NG2) glia can sense synaptic inputs from neurons. Here, the authors show NG2 glia form functional GABAergic synapses by regulating inhibitory synaptic transmission onto adjacent hippocampal interneurons, and activation of NG2 glia induces anxiety-like behaviour in a mouse model of chronic social defeat stress.Xiao ZhangYao LiuXiaoqi HongXia LiCharles K. MeshulCynthia MooreYabing YangYanfei HanWei-Guang LiXin QiHuifang LouShumin DuanTian-Le XuXiaoping TongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao Zhang Yao Liu Xiaoqi Hong Xia Li Charles K. Meshul Cynthia Moore Yabing Yang Yanfei Han Wei-Guang Li Xin Qi Huifang Lou Shumin Duan Tian-Le Xu Xiaoping Tong NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety
description	Nerve/glial antigen 2 (NG2) glia can sense synaptic inputs from neurons. Here, the authors show NG2 glia form functional GABAergic synapses by regulating inhibitory synaptic transmission onto adjacent hippocampal interneurons, and activation of NG2 glia induces anxiety-like behaviour in a mouse model of chronic social defeat stress.
format	article
author	Xiao Zhang Yao Liu Xiaoqi Hong Xia Li Charles K. Meshul Cynthia Moore Yabing Yang Yanfei Han Wei-Guang Li Xin Qi Huifang Lou Shumin Duan Tian-Le Xu Xiaoping Tong
author_facet	Xiao Zhang Yao Liu Xiaoqi Hong Xia Li Charles K. Meshul Cynthia Moore Yabing Yang Yanfei Han Wei-Guang Li Xin Qi Huifang Lou Shumin Duan Tian-Le Xu Xiaoping Tong
author_sort	Xiao Zhang
title	NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety
title_short	NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety
title_full	NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety
title_fullStr	NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety
title_full_unstemmed	NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety
title_sort	ng2 glia-derived gaba release tunes inhibitory synapses and contributes to stress-induced anxiety
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5ba3773ac7ef4f6cb15b4d88942f3545
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NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

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