NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

Nerve/glial antigen 2 (NG2) glia can sense synaptic inputs from neurons. Here, the authors show NG2 glia form functional GABAergic synapses by regulating inhibitory synaptic transmission onto adjacent hippocampal interneurons, and activation of NG2 glia induces anxiety-like behaviour in a mouse mode...

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Main Authors: Xiao Zhang, Yao Liu, Xiaoqi Hong, Xia Li, Charles K. Meshul, Cynthia Moore, Yabing Yang, Yanfei Han, Wei-Guang Li, Xin Qi, Huifang Lou, Shumin Duan, Tian-Le Xu, Xiaoping Tong
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/5ba3773ac7ef4f6cb15b4d88942f3545
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