Programmed death-ligand 1 expression and tumor-infiltrating lymphocytes in non-small cell lung cancer: association with clinicopathologic parameters
Background Data on the prevalence of programmed death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) in non–small cell lung cancer (NSCLC) and their clinical significance in Indian patients are limited. Methods Newly diagnosed NSCLC cases (adenocarcinoma or squamous cell carci...
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Korean Society of Pathologists & the Korean Society for Cytopathology
2021
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oai:doaj.org-article:5ba431d03e634a9d9916c37bcc0e4d5c2021-11-18T05:29:08ZProgrammed death-ligand 1 expression and tumor-infiltrating lymphocytes in non-small cell lung cancer: association with clinicopathologic parameters2383-78372383-784510.4132/jptm.2021.08.08https://doaj.org/article/5ba431d03e634a9d9916c37bcc0e4d5c2021-11-01T00:00:00Zhttp://www.jpatholtm.org/upload/pdf/jptm-2021-08-08.pdfhttps://doaj.org/toc/2383-7837https://doaj.org/toc/2383-7845Background Data on the prevalence of programmed death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) in non–small cell lung cancer (NSCLC) and their clinical significance in Indian patients are limited. Methods Newly diagnosed NSCLC cases (adenocarcinoma or squamous cell carcinoma [SqCC] histology) were included in the present study. The TILs were evaluated based on morphology on hematoxylin and eosin–stained slides. PD-L1 expression in tumors was assessed using immunohistochemistry with rabbit monoclonal antibody (SP263) on the Ventana automated immunostainer. Tumors with PD-L1 expression > 50% on tumor cells were considered PD-L1–positive. Tumors in which TILs occupy > 25% of stroma were considered to have high TILs. The association of PD-L1 expression and TILs with various clinical parameters including overall survival (OS) was investigated. Results The present study included 128 cases of NSCLC (67 adenocarcinoma, 61 SqCC). PD-L1 positivity was observed in 17.2% of the patients with NSCLC. Baseline characteristics of PD-L1–positive subjects were similar to PD-L1–negative subjects except for a higher prevalence of liver metastasis (18.2% vs. 2.8%; p = .018) and a higher probability of diagnosis from extrapulmonary biopsies. High TILs were observed in 26.6% of the subjects. However, PD-L1 expression and high TIL did not affect OS. Conclusions PD-L1 positivity and high TILs were observed in 20% and 25% of the patients with NSCLC, respectively, however, neither were predictors of survival in SqCC.Gaurav GargKuruswamy Thurai PrasadNavneet SinghParul GuptaValliappan MuthuAshim DasAmanjit BalKorean Society of Pathologists & the Korean Society for Cytopathologyarticlelung neoplasmsnon-small cell lung carcinomapd-l1immunotherapytumor-infiltrating lymphocytesPathologyRB1-214ENKOJournal of Pathology and Translational Medicine, Vol 55, Iss 6, Pp 398-405 (2021) |
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DOAJ |
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EN KO |
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lung neoplasms non-small cell lung carcinoma pd-l1 immunotherapy tumor-infiltrating lymphocytes Pathology RB1-214 |
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lung neoplasms non-small cell lung carcinoma pd-l1 immunotherapy tumor-infiltrating lymphocytes Pathology RB1-214 Gaurav Garg Kuruswamy Thurai Prasad Navneet Singh Parul Gupta Valliappan Muthu Ashim Das Amanjit Bal Programmed death-ligand 1 expression and tumor-infiltrating lymphocytes in non-small cell lung cancer: association with clinicopathologic parameters |
| description |
Background Data on the prevalence of programmed death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) in non–small cell lung cancer (NSCLC) and their clinical significance in Indian patients are limited. Methods Newly diagnosed NSCLC cases (adenocarcinoma or squamous cell carcinoma [SqCC] histology) were included in the present study. The TILs were evaluated based on morphology on hematoxylin and eosin–stained slides. PD-L1 expression in tumors was assessed using immunohistochemistry with rabbit monoclonal antibody (SP263) on the Ventana automated immunostainer. Tumors with PD-L1 expression > 50% on tumor cells were considered PD-L1–positive. Tumors in which TILs occupy > 25% of stroma were considered to have high TILs. The association of PD-L1 expression and TILs with various clinical parameters including overall survival (OS) was investigated. Results The present study included 128 cases of NSCLC (67 adenocarcinoma, 61 SqCC). PD-L1 positivity was observed in 17.2% of the patients with NSCLC. Baseline characteristics of PD-L1–positive subjects were similar to PD-L1–negative subjects except for a higher prevalence of liver metastasis (18.2% vs. 2.8%; p = .018) and a higher probability of diagnosis from extrapulmonary biopsies. High TILs were observed in 26.6% of the subjects. However, PD-L1 expression and high TIL did not affect OS. Conclusions PD-L1 positivity and high TILs were observed in 20% and 25% of the patients with NSCLC, respectively, however, neither were predictors of survival in SqCC. |
| format |
article |
| author |
Gaurav Garg Kuruswamy Thurai Prasad Navneet Singh Parul Gupta Valliappan Muthu Ashim Das Amanjit Bal |
| author_facet |
Gaurav Garg Kuruswamy Thurai Prasad Navneet Singh Parul Gupta Valliappan Muthu Ashim Das Amanjit Bal |
| author_sort |
Gaurav Garg |
| title |
Programmed death-ligand 1 expression and tumor-infiltrating lymphocytes in non-small cell lung cancer: association with clinicopathologic parameters |
| title_short |
Programmed death-ligand 1 expression and tumor-infiltrating lymphocytes in non-small cell lung cancer: association with clinicopathologic parameters |
| title_full |
Programmed death-ligand 1 expression and tumor-infiltrating lymphocytes in non-small cell lung cancer: association with clinicopathologic parameters |
| title_fullStr |
Programmed death-ligand 1 expression and tumor-infiltrating lymphocytes in non-small cell lung cancer: association with clinicopathologic parameters |
| title_full_unstemmed |
Programmed death-ligand 1 expression and tumor-infiltrating lymphocytes in non-small cell lung cancer: association with clinicopathologic parameters |
| title_sort |
programmed death-ligand 1 expression and tumor-infiltrating lymphocytes in non-small cell lung cancer: association with clinicopathologic parameters |
| publisher |
Korean Society of Pathologists & the Korean Society for Cytopathology |
| publishDate |
2021 |
| url |
https://doaj.org/article/5ba431d03e634a9d9916c37bcc0e4d5c |
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