The spectrum of psychosis in multiple sclerosis: a clinical case series

Thomas G Gilberthorpe,1 Kara E O’Connell,2,3 Alison Carolan,1 Eli Silber,4 Peter A Brex,4 Naomi A Sibtain,4 Anthony S David3 1Department of Liaison Psychiatry, South London and Maudsley NHS Foundation Trust, Maudsley Hospital, London, UK; 2Department of Psychiatry, School of Medicine, Tri...

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Autores principales:	Gilberthorpe TG, O'Connell KE, Carolan A, Silber E, Brex PA, Sibtain NA, David AS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Psychosis multiple sclerosis neuropsychiatric cognitive schizophrenia-like demyelination Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5ba8608f96fe420cbe2c27c167f68421
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spelling	oai:doaj.org-article:5ba8608f96fe420cbe2c27c167f684212021-12-02T08:31:29ZThe spectrum of psychosis in multiple sclerosis: a clinical case series1178-2021https://doaj.org/article/5ba8608f96fe420cbe2c27c167f684212017-02-01T00:00:00Zhttps://www.dovepress.com/the-spectrum-of-psychosis-in-multiple-sclerosis-a-clinical-case-series-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Thomas G Gilberthorpe,1 Kara E O’Connell,2,3 Alison Carolan,1 Eli Silber,4 Peter A Brex,4 Naomi A Sibtain,4 Anthony S David3 1Department of Liaison Psychiatry, South London and Maudsley NHS Foundation Trust, Maudsley Hospital, London, UK; 2Department of Psychiatry, School of Medicine, Trinity College Dublin, Ireland; 3Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, 4Department of Neurology, Kings College Hospital, London, UK Abstract: Psychosis in the context of multiple sclerosis (MS) has previously been reported as a rare occurrence. However, recent epidemiological studies have found prevalence rates of psychosis in MS that are two to three times higher than those in the general population. Untreated psychosis in patients with MS can adversely impact on adherence to MS medication, levels of disability, and quality of life. This retrospective case series describes the spectrum of psychotic disorders occurring in association with MS using demographic, clinical, and neuroimaging data. In the discussion, we highlight the particular diagnostic and treatment challenges that such disorders can pose for clinicians and through our case vignettes provide examples of potential interventions for this complex patient population. Keywords: psychosis, multiple sclerosis, neuropsychiatric, cognitive, schizophrenia-like, demyelinationGilberthorpe TGO'Connell KECarolan ASilber EBrex PASibtain NADavid ASDove Medical PressarticlePsychosismultiple sclerosisneuropsychiatriccognitiveschizophrenia-likedemyelinationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 303-318 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychosis multiple sclerosis neuropsychiatric cognitive schizophrenia-like demyelination Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Psychosis multiple sclerosis neuropsychiatric cognitive schizophrenia-like demyelination Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Gilberthorpe TG O'Connell KE Carolan A Silber E Brex PA Sibtain NA David AS The spectrum of psychosis in multiple sclerosis: a clinical case series
description	Thomas G Gilberthorpe,1 Kara E O’Connell,2,3 Alison Carolan,1 Eli Silber,4 Peter A Brex,4 Naomi A Sibtain,4 Anthony S David3 1Department of Liaison Psychiatry, South London and Maudsley NHS Foundation Trust, Maudsley Hospital, London, UK; 2Department of Psychiatry, School of Medicine, Trinity College Dublin, Ireland; 3Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, 4Department of Neurology, Kings College Hospital, London, UK Abstract: Psychosis in the context of multiple sclerosis (MS) has previously been reported as a rare occurrence. However, recent epidemiological studies have found prevalence rates of psychosis in MS that are two to three times higher than those in the general population. Untreated psychosis in patients with MS can adversely impact on adherence to MS medication, levels of disability, and quality of life. This retrospective case series describes the spectrum of psychotic disorders occurring in association with MS using demographic, clinical, and neuroimaging data. In the discussion, we highlight the particular diagnostic and treatment challenges that such disorders can pose for clinicians and through our case vignettes provide examples of potential interventions for this complex patient population. Keywords: psychosis, multiple sclerosis, neuropsychiatric, cognitive, schizophrenia-like, demyelination
format	article
author	Gilberthorpe TG O'Connell KE Carolan A Silber E Brex PA Sibtain NA David AS
author_facet	Gilberthorpe TG O'Connell KE Carolan A Silber E Brex PA Sibtain NA David AS
author_sort	Gilberthorpe TG
title	The spectrum of psychosis in multiple sclerosis: a clinical case series
title_short	The spectrum of psychosis in multiple sclerosis: a clinical case series
title_full	The spectrum of psychosis in multiple sclerosis: a clinical case series
title_fullStr	The spectrum of psychosis in multiple sclerosis: a clinical case series
title_full_unstemmed	The spectrum of psychosis in multiple sclerosis: a clinical case series
title_sort	spectrum of psychosis in multiple sclerosis: a clinical case series
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/5ba8608f96fe420cbe2c27c167f68421
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_version_	1718398486241607680

The spectrum of psychosis in multiple sclerosis: a clinical case series

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