Potential of anti-inflammatory treatment for cystic fibrosis lung disease

Jennifer L Taylor-Cousar1,2, Kelsey A Von Kessel2, Robert Young1, David P Nichols1,21Department of Medicine, National Jewish Health, Denver, Colorado, USA; 2Department of Pediatrics, National Jewish Health, Denver, Colorado, USAAbstract: Cystic fibrosis (CF) is the most common life-shortening geneti...

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Autores principales:	Jennifer L Taylor-Cousar, Kelsey A Von Kessel, Robert Young, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5baa09982483470f853a717619a5227a
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spelling	oai:doaj.org-article:5baa09982483470f853a717619a5227a2021-12-02T03:50:42ZPotential of anti-inflammatory treatment for cystic fibrosis lung disease1178-7031https://doaj.org/article/5baa09982483470f853a717619a5227a2010-08-01T00:00:00Zhttp://www.dovepress.com/potential-of-anti-inflammatory-treatment-for-cystic-fibrosis-lung-dise-a5006https://doaj.org/toc/1178-7031Jennifer L Taylor-Cousar1,2, Kelsey A Von Kessel2, Robert Young1, David P Nichols1,21Department of Medicine, National Jewish Health, Denver, Colorado, USA; 2Department of Pediatrics, National Jewish Health, Denver, Colorado, USAAbstract: Cystic fibrosis (CF) is the most common life-shortening genetic disorder in &shy;Caucasians. With improved diagnosis and treatment, survival has steadily increased. &shy;Unfortunately, the overwhelming majority of patients still die from respiratory failure caused by structural damage resulting from airway obstruction, recurrent infection, and inflammation. Here, we discuss the role of inflammation and the development of anti-inflammatory therapies to treat CF lung disease. The inflammatory host response is the least addressed component of CF airway disease at this time. Current challenges in both preclinical and clinical investigation make the identification of suitable anti-inflammatory drugs more difficult. Despite this, many researchers are making significant progress toward this goal and the CF research community has reason to believe that new therapies will emerge from these efforts.Keywords: therapy, cystic fibrosis, survival, inflammation Jennifer L Taylor-CousarKelsey A Von KesselRobert Younget alDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2010, Iss default, Pp 61-74 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Jennifer L Taylor-Cousar Kelsey A Von Kessel Robert Young et al Potential of anti-inflammatory treatment for cystic fibrosis lung disease
description	Jennifer L Taylor-Cousar1,2, Kelsey A Von Kessel2, Robert Young1, David P Nichols1,21Department of Medicine, National Jewish Health, Denver, Colorado, USA; 2Department of Pediatrics, National Jewish Health, Denver, Colorado, USAAbstract: Cystic fibrosis (CF) is the most common life-shortening genetic disorder in &shy;Caucasians. With improved diagnosis and treatment, survival has steadily increased. &shy;Unfortunately, the overwhelming majority of patients still die from respiratory failure caused by structural damage resulting from airway obstruction, recurrent infection, and inflammation. Here, we discuss the role of inflammation and the development of anti-inflammatory therapies to treat CF lung disease. The inflammatory host response is the least addressed component of CF airway disease at this time. Current challenges in both preclinical and clinical investigation make the identification of suitable anti-inflammatory drugs more difficult. Despite this, many researchers are making significant progress toward this goal and the CF research community has reason to believe that new therapies will emerge from these efforts.Keywords: therapy, cystic fibrosis, survival, inflammation
format	article
author	Jennifer L Taylor-Cousar Kelsey A Von Kessel Robert Young et al
author_facet	Jennifer L Taylor-Cousar Kelsey A Von Kessel Robert Young et al
author_sort	Jennifer L Taylor-Cousar
title	Potential of anti-inflammatory treatment for cystic fibrosis lung disease
title_short	Potential of anti-inflammatory treatment for cystic fibrosis lung disease
title_full	Potential of anti-inflammatory treatment for cystic fibrosis lung disease
title_fullStr	Potential of anti-inflammatory treatment for cystic fibrosis lung disease
title_full_unstemmed	Potential of anti-inflammatory treatment for cystic fibrosis lung disease
title_sort	potential of anti-inflammatory treatment for cystic fibrosis lung disease
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/5baa09982483470f853a717619a5227a
work_keys_str_mv	AT jenniferltaylorcousar potentialofantiinflammatorytreatmentforcysticfibrosislungdisease AT kelseyavonkessel potentialofantiinflammatorytreatmentforcysticfibrosislungdisease AT robertyoung potentialofantiinflammatorytreatmentforcysticfibrosislungdisease AT etal potentialofantiinflammatorytreatmentforcysticfibrosislungdisease
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Potential of anti-inflammatory treatment for cystic fibrosis lung disease

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