Small molecule screen in embryonic zebrafish using modular variations to target segmentation

Chemical screens can identify small molecules that affect biological development, with potential therapeutic value. Here, the authors use a modular approach in a screen in zebrafish embryos, varying concentration, genotype and timing to target segmentation disorders, birth defects that affect the sp...

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Autores principales: Sandra Richter, Ulrike Schulze, Pavel Tomançak, Andrew C. Oates
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5bae9903a80946e59f02a1b3b1705726
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Sumario:Chemical screens can identify small molecules that affect biological development, with potential therapeutic value. Here, the authors use a modular approach in a screen in zebrafish embryos, varying concentration, genotype and timing to target segmentation disorders, birth defects that affect the spinal column.