Subclinical Signs of Retinal Involvement in Hereditary Angioedema
To explore retinal abnormalities using spectral domain optical coherence tomography (SD-OCT) and OCT-angiography (OCT-A) in a highly selective cohort of patients with type I hereditary angioedema (HAE). This prospective case-control study included 40 type I HAE patients and 40 age-/sex-matched healt...
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| Autores principales: | , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/5bb7077dc87441f48c40c0bacf46dafd |
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| Sumario: | To explore retinal abnormalities using spectral domain optical coherence tomography (SD-OCT) and OCT-angiography (OCT-A) in a highly selective cohort of patients with type I hereditary angioedema (HAE). This prospective case-control study included 40 type I HAE patients and 40 age-/sex-matched healthy subjects (HC). All participants underwent SD-OCT-scanning of retinal posterior pole (PP), peripapillary retinal nerve fiber layer (pRNFL), and optic nerve head (ONH). Superficial/deep capillary density was analyzed by OCT-A. A total of 80 eyes from 40 HAE and 40 eyes from HC were evaluated. The pRNFL was thicker in HAE than in HC in nasal superior (<i>p</i> < 0.0001) and temporal quadrants (<i>p</i> = 0.0005 left, <i>p</i> = 0.003 right). The ONH thickness in HAE patients was greater than in HC in the nasal (<i>p</i> = 0.008 left, <i>p</i> = 0.01 right), temporal (<i>p</i> = 0.0005 left, <i>p</i> = 0.003 right), temporal inferior (<i>p</i> = 0.007 left, <i>p</i> = 0.0008 right), and global (<i>p</i> = 0.005 left, <i>p</i> = 0.007 right) scans. Compared to HC, HAE showed a lower capillary density in both superficial (<i>p</i> = 0.001 left, <i>p</i> = 0.006 right) and deep (<i>p</i> = 0.008 left, <i>p</i> = 0.004 right) whole images, and superficial (<i>p</i> = 0.03 left) and deep parafoveal (<i>p</i> = 0.007 left, <i>p</i> = 0.005 right) areas. Our findings documented subclinical retinal abnormalities in type I HAE, supporting a potential role of the retinal assessment by SD-OCT/OCT-A as a useful tool in the comprehensive care of HAE patients. |
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